Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy

Begg DJ; Griffin JF

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Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy

机译：羊副结核分枝杆菌的疫苗接种：免疫参数和保护功效

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Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec and an aqueous formulation of Map 316F (AquaVax) were tested in sheep. Detailed immunological examination of blood and gut-associated lymphoid tissues was carried out on animals after vaccination and challenge with virulent Map to identify markers of protective immunity. Neoparasec vaccination provided significant protection against disease while AquaVax did not. Immune animals had stronger cell-mediated responses and altered proportions of CD4+, CD8+, CD25+ and B cells in blood, spleen and the gut lymphatics, than diseased animals.

机译：反刍动物中的约翰氏病是由致病性禽鸟分枝杆菌副结核病菌引起的（图）。当前可用的Map商业疫苗可预防临床疾病，但不能预防感染。在这项研究中，在绵羊中测试了专有的Johne疫苗Neoparasec和Map 316F（AquaVax）的水性制剂。接种疫苗并用毒力图谱攻击后，对动物进行了血液和与肠道相关的淋巴样组织的详细免疫学检查，以鉴定保护性免疫的标志物。 Neoparasec疫苗接种可有效预防疾病，而AquaVax则不能。免疫动物比患病动物具有更强的细胞介导反应，并且血液，脾脏和肠道淋巴管中的CD4 +，CD8 +，CD25 +和B细胞比例有所改变。

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《Vaccine》 |2005年第42期|共10页
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Begg DJ; Griffin JF;
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中图分类卫生标准、卫生检查、医药管理;
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1. Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy [J] . Begg DJ, Griffin JF Vaccine . 2005,第42期

机译：羊副结核分枝杆菌的疫苗接种：免疫参数和保护功效
2. Identification of Surrogates and Correlates of Protection in Protective Immunity against Mycobacterium bovis Infection Induced in Neonatal Calves by Vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish [J] . J. C. Hope, M. L. Thom, M. McAulay, Clinical and vaccine immunology: CVI . 2011,第3期

机译：通过牛分枝杆菌BCG巴斯德氏菌和牛分枝杆菌BCG丹麦疫苗接种，鉴定新生牛犊中针对牛分枝杆菌感染的保护性免疫的替代物和保护性相关性
3. Identification of Immune Parameters To Differentiate Disease States among Sheep Infected with Mycobacterium avium subsp. paratuberculosis [J] . Sonia Gillan, Rory OBrien, Alan D. Hughes, Clinical and vaccine immunology: CVI . 2010,第1期

机译：确定免疫参数以区分感染鸟分枝杆菌亚种的绵羊的疾病状态。副结核病
4. Immune parameters and vaccine efficacy in Mycobacterium avium subspecies paratuberculosis experimentally infected sheep [C] . Begg D, Griffin JFT International Colloquium on Paratuberculosis . 2007

机译：免疫参数和疫苗疗效在分枝杆菌亚种副肢体分枝杆菌实验感染绵羊
5. Protection from Pseudomonas aeruginosa pneumonia after vaccination with recombinant live attenuated Salmonella: Correlates of protective immunity in the respiratory tract. [D] . DiGiandomenico, Antonio. 2006

机译：重组减毒活沙门氏菌疫苗接种后对铜绿假单胞菌肺炎的保护：与呼吸道保护性免疫有关。
6. Identification of Surrogates and Correlates of Protection in Protective Immunity against Mycobacterium bovis Infection Induced in Neonatal Calves by Vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish [O] . J. C. Hope, M. L. Thom, M. McAulay, 2011

机译：通过牛分枝杆菌BCG巴斯德氏菌和牛分枝杆菌BCG丹麦疫苗接种鉴定新生牛犊中针对牛分枝杆菌感染的保护性免疫的替代物和保护性相关性
7. Identification of Surrogates and Correlates of Protection in Protective Immunity against Mycobacterium bovis Infection Induced in Neonatal Calves by Vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish ▿ [O] . Hope, J. C., Thom, M. L., McAulay, M., 2011

机译：通过牛分枝杆菌BCG巴斯德巴斯德菌和牛分枝杆菌BCG疫苗接种的鉴定，鉴定了新生牛犊针对牛分枝杆菌感染所产生的针对牛分枝杆菌感染的保护性免疫保护的替代物和相关性
8. Evaluation of the Efficacy, Potential for Vector Transmission, and Duration of Immunity of MP-12, an Attenuated Rift Valley Fever Virus Vaccine Candidate, in Sheep. [R] . Miller, M. M., Bennett, K. E., Drolet, B. S., 2015

机译：评估绵羊中减毒裂谷热病毒疫苗候选物mp-12的功效，载体传递潜力和免疫持续时间。

Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy

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