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首页> 外文期刊>Vaccine >Dramatic decline in acute hepatitis B infection and disease incidence rates among adolescents and young people after 12 years of a mass hepatitis B vaccination programme of pre-adolescents in the schools of Catalonia (Spain)
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Dramatic decline in acute hepatitis B infection and disease incidence rates among adolescents and young people after 12 years of a mass hepatitis B vaccination programme of pre-adolescents in the schools of Catalonia (Spain)

机译：在加泰罗尼亚（西班牙）的青少年中进行了为期12年的青少年前期大规模乙型肝炎疫苗接种计划后，青少年和年轻人的急性B型肝炎感染和疾病发病率急剧下降

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摘要

The aim of the study was to describe the impact of hepatitis B vaccination and disease incidence in adolescents and young people 12 years after the launching of a mass hepatitis B vaccination of pre-adolescents in schools. Vaccination coverage was assessed using administrative and serological data. Infection trends were evaluated by means of seroepidemiological surveys. High levels of vaccination coverage and vaccine-induced immunity were achieved. The resulting low proportions of susceptible adolescents and young people have undoubtedly contributed to the substantial reduction in the prevalence of hepatitis B infection in the 15-24 years age group (0.9 per 100 in 2001 versus 9.3 per 100 in 1986) and in the reported incidence of hepatitis B cases (80% reduction). Over the last 3 years, the declining trend seems to have been halted, although 35% of cases reported during this period corresponded to immigrants.
机译：这项研究的目的是描述在学校对青少年进行大规模的乙肝疫苗接种12年后，乙肝疫苗接种和青少年发病率的影响。使用行政管理和血清学数据评估疫苗接种覆盖率。通过血清流行病学调查评估了感染趋势。实现了高水平的疫苗接种覆盖率和疫苗诱导的免疫力。由此产生的低比例的易受感染的青少年和年轻人无疑导致了15-24岁年龄段的乙型肝炎感染率的大幅下降（2001年为每100人中0.9例，而1986年为每100人中9.3例）乙肝病例（减少80％）。在过去三年中，下降趋势似乎已经停止，尽管在此期间报告的病例中有35％与移民有关。

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