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首页> 外文期刊>Vaccine >Pertussis antitoxin decay after vaccination with DTPa. Response to a first booster dose 3 1/2-6 1/2 years after the third vaccine dose
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Pertussis antitoxin decay after vaccination with DTPa. Response to a first booster dose 3 1/2-6 1/2 years after the third vaccine dose

机译：DTPa疫苗接种后百日咳抗毒素衰减。在第三次疫苗注射后3 1 / 2-6 1/2年对第一次加强剂量的反应

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Longitudinal serum samples were collected from 542 children that had participated in a Swedish pertussis vaccine trial 1992-1995 [Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J. A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med 1996;334(6):349-355] and who did not contract pertussis. The sera were analyzed for post vaccination antibody decay and for booster response of anti-PT (IgG antibodies against pertussis toxin), as measured by ELISA. Generally, an initial rapid decay of antitoxin antibody concentration was followed by a slower decay; the change occurring when the geometric mean level of antitoxin concentration reached 8-9 ELISA Units/mL (EU/mL). The time needed to reach this level was 8-9 months after the third dose in a 2, 4, and 6 months schedule. A "best-fit" combined regression model was used to predict when 50% of the children have less than the minimum level of detection of anti-PT (1EU/mL). This occurred about 65 months after dose 3 at an age of 6 years. The anti-PT response to a booster dose was evident but the post-booster geometric mean values decreased with number of years after the third dose and the response appeared later. The results indicate that a pre-school booster might be considered at 6 years of age or earlier.
机译：纵向血清样本是从1992年至1995年参加瑞典百日咳疫苗试验的542名儿童中收集的[Gustafsson L，Hallander HO，Olin P，Reizenstein E，StorsaeterJ。两组分无细胞，五组分的对照试验。无细胞疫苗和全细胞百日咳疫苗。 N Engl J Med 1996; 334（6）：349-355]，但没有感染百日咳。通过ELISA测量，分析血清的疫苗接种后抗体衰减和抗PT（针对百日咳毒素的IgG抗体）的加强应答。通常，抗毒素抗体浓度的初始快速衰减是随后的缓慢衰减。当抗毒素浓度的几何平均水平达到8-9 ELISA单位/ mL（EU / mL）时发生的变化。达到此水平所需的时间是在第2、4和6个月的时间表中第三次给药后8-9个月。使用“最佳拟合”组合回归模型预测何时有50％的儿童的抗PT检测水平低于最低检测水平（1EU / mL）。这发生在剂量3后约65个月，年龄6岁。对增强剂量的抗PT反应是明显的，但随着第三次给药后的年数增加，升压后的几何平均值下降，并且反应出现较晚。结果表明，可以考虑在6岁或更早的时候使用学龄前儿童。

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