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首页> 外文期刊>Vaccine >Imprinting of BALB/c mice with low Leishmania infantum parasite dose markedly protects spleen against high-dose challenge.
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Imprinting of BALB/c mice with low Leishmania infantum parasite dose markedly protects spleen against high-dose challenge.

机译：低婴儿利什曼原虫寄生虫剂量的BALB / c小鼠的印记显着保护脾脏免受高剂量攻击。

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摘要

In this study, we investigated in the BALB/c model, the dose-dependent protective potential of previous infection with Leishmania infantum parasites, against a high-dose challenge and showed for the first time that low-dose imprinting conferred substantial spleen resistance. Mice were immunized for 1 month or 5 months by IV route with parasite inocula ranging from 104 to 107 and from 103 to 105, respectively, and challenged for 1 month with 3x107 parasites. Liver protection was directly proportional to the parasite dose used for infection and reached 90-95% whereas, only low doses (<=105) protected spleen. Maximal spleen resistance (80%) was reached in mice infected for 5 months with 105 parasites. In most cases, protection was accompanied in spleen, by restored in vitro responses to Leishmania antigens. Analysis of anti L. infantum isotype responses and in vitro antigen-induced cytokine production, indicated that the acquired protection was irrespective of a Th1/Th2 imbalance..
机译：在这项研究中，我们在BALB / c模型中调查了先前感染婴儿利什曼原虫的寄生虫对高剂量攻击的剂量依赖性保护潜能，并首次表明低剂量印记赋予了实质性的脾脏抵抗力。通过IV途径用分别从104至107和103至105的寄生虫接种物对小鼠免疫1个月或5个月，并用3x107寄生虫攻击1个月。肝脏保护与感染所用的寄生虫剂量成正比，达到90-95％，而只有低剂量（<= 105）保护脾脏。在用105种寄生虫感染5个月的小鼠中，脾脏的抵抗力达到最大（80％）。在大多数情况下，脾脏受到保护，同时恢复了对利什曼原虫抗原的体外反应。分析婴儿抗乳杆菌同种型反应和体外抗原诱导的细胞因子产生，表明获得的保护与Th1 / Th2失衡无关。

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