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首页> 外文期刊>Vaccine >Human IgG subclass responses in relation to serum bactericidal and opsonicactivities after immunization with three doses of the Norwegian serogroupB meningococcal outer membrane vesicle vaccine
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Human IgG subclass responses in relation to serum bactericidal and opsonicactivities after immunization with three doses of the Norwegian serogroupB meningococcal outer membrane vesicle vaccine

机译：三剂挪威血清型B脑膜炎球菌外膜囊泡疫苗免疫后与血清杀菌和调理活性有关的人IgG亚类应答

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Ten adult volunteers, with low prevaccination levels of serum IgG antibodies against meningococcal antigens (< 1 mu g ml(-1)), received three doses of the Norwegian group B meningococcal outer membrane vesicle (OMV) vaccine intramuscularly at weeks 1). 6 and 46. Anti-OMV IgG subclass responses were measured and compared with serum bactericidal activity (SBA) and opsonic activity against the vaccine strain 44/76. All vaccinees showed an IgG1 antibody response after each vaccine dose. The vaccine-induced median serum IgG1 antibody levels were 16, 17 and 18 mu g ml(-1) 2-6 weeks after the first, second and third dose. respectively. Three vaccinees showed a weak IgG3 response after the first dose, whereas 8 and 9 showed a response after the second (median = 10 mu g ml(-1)) and third dose (median = 10 mu g ml(-1)), respectively. Low levels of anti-OMV IgG2 antibodies were found, whilst specific IgG4 antibodies were only detected for one vaccinee. The vaccine induced at least a fourfold increase in SEA titre in 8 vaccinees after the first dose, in 9 vaccinees after 2 doses and in all vaccinees after 3 doses. A positive correlation was found between IgG1 subclass antibody levels and SEA (r = 0.62, P < 0.0001). Elevated opsonophagocytic activity. measured as respiratory burst (RB), was observed in all vaccinees after one vaccine dose and usually increased after 2 and 3 doses. A strong positive correlation was Found between IgG1 antibody levels and RE (r = 0.76, P < 0.0001). In conclusion, we have shown that systemic meningococcal OMV vaccination in adult vaccinees mainly induced IgG1 antibodies which correlated with bactericidal and opsonic activity, but also a considerable amount of IgG3 antibodies, which, in contrast to the IgG1 response. was induced only after 2 or 3 vaccine doses and declined more rapidly. (C) 1999 Elsevier Science Ltd. All lights reserved. [References: 43]
机译：十名成年志愿者在疫苗接种前针对脑膜炎球菌抗原的血清IgG抗体水平较低（<1μgml（-1）），在第1周时肌肉注射了三剂挪威B组脑膜炎球菌外膜囊泡（OMV）疫苗。分别参见图6和46。测量了抗OMV IgG亚类应答并将其与针对疫苗菌株44/76的血清杀菌活性（SBA）和调理活性相比较。每次接种疫苗后，所有疫苗接种者均显示IgG1抗体反应。第一次，第二次和第三次给药后2-6周，疫苗诱导的血清IgG1抗体中值分别为16、17和18μgml（-1）。分别。三种疫苗在第一剂后显示较弱的IgG3反应，而8和9在第二剂（中位数= 10μgml（-1））和第三剂（中位数= 10μgml（-1））后显示应答，分别。发现低水平的抗OMV IgG2抗体，而仅针对一种疫苗接种者检测到特异性IgG4抗体。该疫苗在第一剂后的8株疫苗，2剂后的9株疫苗和3剂后的所有疫苗中诱导SEA滴度至少增加了四倍。 IgG1亚类抗体水平与SEA之间存在正相关（r = 0.62，P <0.0001）。调理吞噬活动升高。在一剂疫苗后，在所有疫苗中均观察到以呼吸爆发（RB）表示的“呼吸爆发”，通常在2剂和3剂后增加。发现IgG1抗体水平与RE之间存在强正相关（r = 0.76，P <0.0001）。总之，我们已经表明，成年疫苗中的全身性脑膜炎球菌OMV疫苗接种主要诱导与杀菌和调理活性相关的IgG1抗体，但也诱导了大量的IgG3抗体，与IgG1反应相反。仅在注射2或3剂疫苗后即可诱导这种病，并且下降速度更快。 （C）1999 Elsevier ScienceLtd。保留所有灯光。 [参考：43]

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