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首页> 外文期刊>Vaccine >Mouse model of respiratory Chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates
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Mouse model of respiratory Chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates

机译：呼吸道肺炎衣原体感染的小鼠模型用于亚基候选疫苗的基因组筛选

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An inbred A/J mouse respiratory challenge model was validated for vaccine testing against Chlamydia (C.) pneumoniae and used to screen the C. pneumoniae genome for vaccine candidates by expression library immunization (ELI). Biolistic delivery of genetic vaccine constructs elicited Th2-like immunity that was associated with inefficient elimination of C. pneumoniae. Delivery by injection elicited protective Th1-like responses. Since biolistic delivery of pools of ORFs was used in first round screening, the screen presumably selected against potent immunogens. Nevertheless, it was sufficiently accurate to identify three weakly protective antigens among all putative C. pneumoniae ORFs. The results suggest ELI discovery of highly protective C. pneumoniae vaccine candidates requires tight control of the Th1 immunity elicited by the genetically delivered library of test antigens.
机译：一个近交的A / J小鼠呼吸道攻击模型经过验证可用于针对肺炎衣原体的疫苗测试，并通过表达文库免疫（ELI）筛选肺炎衣原体基因组的候选疫苗。基因疫苗构建物的弹射传递引发了Th2样免疫，与无效的肺炎衣原体消除有关。通过注射递送引起保护性的Th1样反应。由于在第一轮筛选中使用了ORF池的射弹传递，因此推测筛选是针对有效的免疫原进行的。然而，在所有推定的肺炎衣原体ORF中鉴定出三种弱保护性抗原是足够准确的。结果表明，ELI发现高度保护性肺炎衣原体疫苗候选者需要严格控制由基因传递的测试抗原文库引起的Th1免疫力。

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