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Surveillance system of vaccine adverse events and local data analysis--the experience in a middle-sized city in Brazil, 1999-2001

机译:疫苗不良事件监测系统和本地数据分析-巴西中型城市的经验,1999-2001年

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摘要

We reviewed all vaccine adverse events (VAE) notified in a middle-sized Brazilian city (n=247) to the National Immunisation Program between January 1999 and December 2001. Vaccine doses used in that period were considered for rate estimates. Aspects of the surveillance system (SS) and their influences on collected data were considered, searching for contributions of local data analysis to investigation of VAE and to the monitoring of vaccine safety. Notification rates in our study were higher when compared to national data. Changes in the notification pattern were observed following vaccination campaign periods. An increase in aseptic meningitis cases temporally associated to yellow fever vaccine was detected. The analysis of local data provided information unperceived in national consolidated data. Through this analysis we detected: events related to application technique and handling; people's perception changes on VAE; and the local SS's ability to raise new hypothesis. We suggested changes to the notification form regarding data entry criteria and analysis.
机译:我们回顾了1999年1月至2001年12月之间在巴西中型城市(n = 247)通知国家免疫计划的所有疫苗不良事件(VAE)。考虑了该时期使用的疫苗剂量以进行比率估算。考虑了监视系统(SS)的各个方面及其对收集数据的影响,以寻求本地数据分析对VAE的调查和对疫苗安全性的监测的贡献。与国家数据相比,我们研究中的通知率更高。在接种疫苗后,观察到了通知模式的变化。发现暂时与黄热病疫苗有关的无菌性脑膜炎病例增加。对本地数据的分析提供了国家综合数据中未发现的信息。通过此分析,我们检测到:与应用技术和处理有关的事件;人们对VAE的看法发生了变化;以及当地SS提出新假设的能力。我们建议更改有关数据输入标准和分析的通知表单。

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