Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age

Scheifele DW; Halperin SA; Smith B; Ochnio J; Meloff K; Duarte-Monteiro D

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Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age

机译：评估2-7个月大的婴儿7价肺炎球菌结合物，DTaP.IPV / PRP-T Hib和乙型肝炎疫苗的共用性

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This study assessed compatibility of concurrently administered 7-valent pneumococcal conjugate (PCV7), hepatitis B (HB) and DTaP.IPV/Hib vaccines. Infants were given DTaP.IPV/Hib and HB at 2, 4, 6 months and randomly assigned (2:1) to receive PCV7 concurrently or sequentially (at 3, 5, 7 months). Antibody levels were compared in 246 concurrent and 122 sequential vaccinees. Responses to PCV7, DTaP.IPV/Hib and HB were generally unaltered with concurrent administration except that Hib responses were increased (p=0.008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections.

机译：这项研究评估了同时使用的7价肺炎球菌结合物（PCV7），乙型肝炎（HB）和DTaP.IPV / Hib疫苗的相容性。分别于2、4、6个月给婴儿提供DTaP.IPV / Hib和HB，并随机分配（2：1）同时或相继（3、5、7个月）接受PCV7。比较了246种同时接种和122种连续接种疫苗的抗体水平。并发给药对PCV7，DTaP.IPV / Hib和HB的反应通常不变，但并发给药增加了Hib响应（p = 0.008）和HB响应降低（p = 0.006），后者可能是通过同时注射大腿DTaP.IPV / Hib。我们得出结论，PCV7，DTaP.IPV / Hib和HB与并发的单独注射剂相容。

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《Vaccine》 |2006年第12期|共8页
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Scheifele DW; Halperin SA; Smith B; Ochnio J; Meloff K; Duarte-Monteiro D;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age [J] . Scheifele DW, Halperin SA, Smith B, Vaccine . 2006,第12期

机译：评估2-7个月大的婴儿7价肺炎球菌结合物，DTaP.IPV / PRP-T Hib和乙型肝炎疫苗的共用性
2. Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age [J] . Russell F. M., Carapetis J. R., Burton R. L., Vaccine . 2011,第3期

机译：降低剂量的12个月大剂量7价肺炎球菌结合疫苗婴儿一级疫苗和23价肺炎球菌多糖疫苗之后的调理吞噬活性
3. An Acellular Pertussis, Diphtheria, Tetanus, Inactivated Poliovirus, Hib-Conjugate Combined Vaccine (Pentaxim) at 2, 4, and 6 Months of Age Plus Hepatitis B at Birth, 2, and 6 Months of Age in Infants in Thailand [J] . U.Thisyakorn, T.Chotpitayasunondh, C.Pancharoen, International journal of infectious diseases : . 2008,第Supplementa1期

机译：2、4、6个月大时无细胞百日咳，白喉，破伤风，灭活脊髓灰质炎，Hib结合疫苗（戊他辛）加婴儿出生时，2、6个月大时乙型肝炎
4. Microbiology of acute otitis media with perforation (AOMwiP) in Aboriginal children living in remote communities-monitoring the impact of 7-valent pneumococcal conjugate vaccine (7vPCV) [C] . Amanda Leach, Grant MacKenzie, Kim Hare, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：具有穿孔（Aomwip）的急性中耳炎的微生物学，在偏远社区生活在偏远社区中的土着儿童 - 监测7价肺炎球菌缀合物疫苗的影响（7VPCV）
5. Impact of long-term routine pneumococcal conjugate vaccine use in Navajo and White Mountain Apache communities: Carriage prevalence, mechanisms of replacement & genetic analysis of nontypeable pneumococci. [D] . Scott, Jennifer R. 2010

机译：纳瓦霍人和怀特山阿帕奇社区长期使用常规肺炎球菌结合疫苗的影响：运输流行性，不可分型肺炎球菌的替代机制和遗传分析。
6. Opsonophagocytic Activity Following a Reduced Dose 7-valent Pneumococcal Conjugate Vaccine Infant Primary Series and 23-valent Pneumococcal Polysaccharide Vaccine at 12 Months of Age [O] . FM Russell, JR Carapetis, RL Burton, -1

机译：减少剂量7价肺炎球菌缀合物疫苗婴儿初级系列和12个月的23年性肺炎球菌多糖疫苗后的Opsonocococytic活性
7. Immunogenicity and safety study of a new DTaP–IPV–Hep B–PRP-T combined vaccine compared to a licensed DTaP–IPV–Hep B//PRP-T comparator, both concomitantly administered with a 7-valent pneumococcal conjugate vaccine at 2, 4, and 6 months of age in Thai infants [O] . Kosalaraksa Pope, Thisyakorn Usa, Benjaponpitak Suwat, 2011

机译：新型DTaP–IPV–Hep B–PRP-T联合疫苗与许可的DTaP–IPV–Hep B // PRP-T对照疫苗的免疫原性和安全性研究，均与7价肺炎球菌结合疫苗一起在2，泰国婴儿的4个月和6个月大
8. Invasive Pneumococcal Disease and 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Coverage Among Children Aged Less Than or Equal to 59 Months, Selected U.S. Regions, 2010-2011 [R] . 2011

机译：侵入性肺炎球菌疾病和13价肺炎球菌结合疫苗（pCV13）覆盖率小于或等于59个月的儿童，2010 - 2011年选定的美国地区

Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age

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