GM-CSF-surface-modified B16.F10 melanoma cell vaccine

Gao J; Huang S; Li M; Luo R; Wang X; Takashima A

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GM-CSF-surface-modified B16.F10 melanoma cell vaccine

机译：GM-CSF-表面修饰的B16.F10黑色素瘤细胞疫苗

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Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell membrane with a biotin derivative and surface modification of the biotinylated cells with the bi-functional fusion protein, streptavidin-tagged GM-CSF. Furthermore, the resultant GM-CSF-modified B16.F10 whole tumor cell vaccine could induce strong and long-lasting systemic protection against the wild-type tumor challenge. Therefore, the platform may represent a fast, efficient and safe approach for the whole tumor cell vaccination.

机译：通过链霉亲和素与生物素之间的特异性和紧密的相互作用，开发了一种新型平台，可在生物素化的B16.F10肿瘤细胞表面上快速（不到2h），有效且持久地展示链霉亲和素标记的生物活性GM-CSF。该技术涉及用生物素衍生物对细胞膜进行生物素化，并用双功能融合蛋白链霉亲和素标记的GM-CSF对生物素化细胞进行表面修饰。此外，所得的GM-CSF修饰的B16.F10全肿瘤细胞疫苗可诱导针对野生型肿瘤攻击的强而持久的全身保护。因此，该平台可代表整个肿瘤细胞疫苗接种的快速，有效和安全的方法。

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《Vaccine》 |2006年第25期|共4页
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Gao J; Huang S; Li M; Luo R; Wang X; Takashima A;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. GM-CSF-surface-modified B16.F10 melanoma cell vaccine [J] . Gao J, Huang S, Li M, Vaccine . 2006,第25期

机译：GM-CSF-表面修饰的B16.F10黑色素瘤细胞疫苗
2. Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest. [J] . Laughlin KM, Luo D, Liu C Differentiation: The Journal of the International Society of Differentiation . 2009,第1期

机译：B16.F10黑色素瘤细胞中的造血和神经系统表达序列1（Hn1）耗竭促进分化的表型，包括增加的黑色素生成和细胞周期停滞。
3. Upregulation of DNA Sensors in B16.F10 Melanoma Spheroid Cells After Electrotransfer of pDNA [J] . Katarina Znidar, Masa Bosnjak, Tanja Jesenko, Technology in cancer research & treatment. . 2018,第17期

机译：pDNA电转移后B16.F10黑色素瘤球状细胞DNA传感器的上调
4. Malignant Melanoma - Clinical Development of Peptide-Based Melanoma Vaccines [C] . Alexander Schmittel, Carmen Scheibenbogen, Anne Letsch, International Symposium on Special Aspects of Radiotherapy . 2006

机译：恶性黑素瘤 - 基于肽的黑素瘤疫苗的临床开发
5. Development of a Melanoma Therapeutic Vaccine Candidate by the Coencapsulation of Melanoma Antigen Peptides and Toll-like Receptor Ligands as Adjuvants into Polymeric Nanoparticles [D] . Silva, Joana Catarina Mend?o Azeit?o da. 2014

机译：由黑色素瘤抗原肽的COENCAITULATULATULATULATION和Toll样受体配体作为聚合物纳米颗粒的辅助剂的开发
6. Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest [O] . Katharine M. Laughlin, Defang Luo, Che Liu, -1

机译：B16.F10黑素瘤细胞中造血和神经系统表达的序列1（HN1）耗尽促进了差异化表型包括增加的黑素生成和细胞周期捕获
7. Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest [O] . Departments of Pharmacology & Therapeutics, University of Florida, College of Medicine, P.O. Box 100267, 1600 SW Archer Rd, Gainesville, FL 32610-0267, USA ( host institution ), Laughlin, Katharine M. ( UF author ), Luo, Defang ( UF author ), 2009

机译：B16.F10黑色素瘤细胞的造血和神经系统表达序列1（Hn1）耗竭促进分化的表型，包括增加的黑色素生成和细胞周期停滞

GM-CSF-surface-modified B16.F10 melanoma cell vaccine

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