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A novel adjuvant complex, tyrosine-MPL, for prophylactic and therapeutic vaccines

机译:一种新型佐剂复合物,酪氨酸-MPL,用于预防和治疗疫苗

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摘要

Therapeutic vaccination for the treatment of allergy has been used for nearly a century but it is only recently that the mechanisms whereby benefits can be achieved have begun to be identified [Bousquet J, Lockey FR, Mailing HJ. Allergy immunotherapy: therapeutic vaccines for allergic diseases. WHO Position Paper. Allergy 1998;53:1-42.]. The induction of blocking antibodies was originally thought to lead to amelioration of allergic symptoms. There is now evidence that a switch from a Th2 (IgE/inflammatory) response to a Thl biased allergen specific response is part of the answer [Durham SR, Till SJ, Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol, 1998; 102:157-64.]. Specific anergy induced by raised IL 10 and TGF3 and the induction of regulatory T cells may also be important [Akdis CA, Blaser K, Allergen-specific immunotherapy. Allergy 2000;55:522-30.]. A new adjuvant complex, L-tyrosine-MPL can accelerate these processes.
机译:用于治疗变态反应的治疗性疫苗已经使用了近一个世纪,但是直到最近才开始确定可以实现益处的机制[Bousquet J,Lockey FR,Mailing HJ。过敏免疫疗法:用于过敏性疾病的治疗性疫苗。世卫组织立场文件。过敏1998; 53:1-42。最初认为阻断抗体的诱导导致过敏症状的减轻。现在有证据表明,从Th2(IgE /炎症)反应向偏向Th1的过敏原特异性反应的转变是答案的一部分[Durham SR,Till SJ,与过敏原免疫疗法相关的免疫学改变。过敏临床免疫杂志,1998; 102:157-64。 IL 10和TGF3升高引起的特异性无能以及调节性T细胞的诱导也可能很重要[Akdis CA,Blaser K,过敏原特异性免疫疗法。过敏2000; 55:522-30。]。新的佐剂复合物L-酪氨酸-MPL可以加速这些过程。

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