Adjuvants: present regulatory challenges

Pascual DM; Morales RD; Gil ED; Munoz LM; Lopez JE; Casanueva OL

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Adjuvants: present regulatory challenges

机译：佐剂：目前的监管挑战

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Research on new adjuvants and delivery systems has expanded dramatically in the last decade. New generation vaccines, based on recombinant proteins, synthetics, and conjugated antigens have emerged but they have limitations because of their poor immunogenic properties, and therefore more cooperative adjuvants for the promotion of the immune response are required. Different molecules have been screened for their ability to enhance the immune response to vaccine antigens, e.g. liposomes, protein cochleate formulations, ISCOMs and cytokines, to name the few. However, most of the vaccines that are currently licensed use aluminum salts or calcium phosphate.

机译：在过去的十年中，对新佐剂和给药系统的研究已大大扩展。已经出现了基于重组蛋白，合成蛋白和结合抗原的新一代疫苗，但是由于它们的免疫原性差而受到限制，因此需要更多的协同佐剂来促进免疫反应。已经筛选出不同的分子增强针对疫苗抗原的免疫应答的能力，例如针对抗原。脂质体，蛋白质耳蜗制剂，ISCOM和细胞因子，仅举几例。但是，当前获得许可的大多数疫苗都使用铝盐或磷酸钙。

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《Vaccine》 |2006年第2期|共2页
作者
Pascual DM; Morales RD; Gil ED; Munoz LM; Lopez JE; Casanueva OL;
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中图分类卫生标准、卫生检查、医药管理;
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1. Adjuvants: present regulatory challenges [J] . Pascual DM, Morales RD, Gil ED, Vaccine . 2006,第Suppla2期

机译：佐剂：目前的监管挑战
2. Comparison of four adjuvants revealed thestrongest protection against lethal pneumococcal challenge following immunization with PsaA-PspA fusion protein and AS02 as adjuvant [J] . Chen Xiaorui, Li Bo, Yu Jinfei, Medical Microbiology and Immunology . 2019,第2期

机译：四种佐剂的比较揭示了在用PSAA-PSPA融合蛋白和AS02免疫后免疫致命肺炎球菌攻击的致命保护，如佐剂
3. Co-delivery of amphipol-conjugated adjuvant with antigen, and adjuvant combinations, enhance immune protection elicited by a membrane protein-based vaccine against a mucosal challenge with Chlamydia [J] . Tifrea Delia F., Pal Sukumar, Le Bon Christel, Vaccine . 2018,第45期

机译：用抗原和佐剂组合共同递送两栖缀合的佐剂，增强由膜蛋白的疫苗引起的免疫保护，与衣原体粘膜攻击
4. Trends in the chemicals regulatory arena affecting tank mix adjuvant markets [C] . J A Rosenblom British Crop Protection Council International Congress of the Crop Science and Technology . 2003

机译：影响坦克混合佐剂市场的化学品监管舞台的趋势
5. Intransal Immunization of Pigs With Porcine Reproductive and Respiratory Syndrome Virus Like Particles Plus 2', 3'-cGAMP VacciGrade(TM) Adjuvant Exacerbates Viremia After Virus Challenge. [D] . Van Noort, Alexandria Marie. 2017

机译：猪繁殖与呼吸综合征病毒像颗粒加上2'，3'-cGAMP VacciGrade（TM）佐剂对猪进行鼻内免疫可加剧病毒攻击后的病毒血症。
6. Overseeing health care facilities in Shanghai China: regulatory regime activities and challenges of the governmental regulatory system [O] . Yizhong Zhou, Zechang Lu, Zhifeng Yang, 2019

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7. CN3 - VALUE OF ADJUVANT ONCOLOGY THERAPIES: METHODOLOGICAL CHALLENGES OF MODELLING COST-EFFECTIVENESS OF AN ADJUVANT TREATMENT IN AN ERA OF HIGH-COST ONCOLOGY TREATMENTS [O] . V. Kovacs, Z. Kiss, E. Tichy, 2018

机译：CN3 - 佐剂肿瘤疗法的价值：在高成本肿瘤治疗时代佐剂治疗成本效果建模的方法论挑战

Adjuvants: present regulatory challenges

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