...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Humoral response to hepatitis B vaccination and its relationship with T CD45RA+ (naive) and CD45RO+ (memory) subsets in HIV-1-infected subjects
【24h】

Humoral response to hepatitis B vaccination and its relationship with T CD45RA+ (naive) and CD45RO+ (memory) subsets in HIV-1-infected subjects

机译：感染HIV-1的受试者对乙型肝炎疫苗的体液反应及其与T CD45RA +（天然）和CD45RO +（记忆）亚群的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

HIV disease leads to defects in cell-mediated immunity, impairing the immune response to new and recall antigens. We studied 55 HIV 1-infected patients who received of recombinant DNA hepatitis B vaccine and 20 controls. The overall hepatitis B virus (HBV) seroconversion rate was 59%. The median CD4+ T cell count among responders was 452 cell/mm(3), higher than non-responders (359 cells/mm(3)). The HIV plasmaviral loads were higher in non-responders. We concluded that total T CD4 cell count, memory T CD4+ cells and lower plasma viral load among HIV-1-infected subjects treated with HAART could be used to predict the immune response to vaccination with hepatitis B vaccine. Thus, considering cost benefits, HVB vaccination should be preferentially provided to HIV-infected patients with T CD4 cells count over 450 cells/mm(3), preferentially whose under HIV replication controlled.
机译：HIV疾病会导致细胞介导的免疫缺陷，削弱对新抗原和召回抗原的免疫反应。我们研究了55名接受重组DNA乙型肝炎疫苗的HIV 1感染患者和20名对照。总体乙型肝炎病毒（HBV）血清转化率为59％。应答者中的CD4 + T细胞计数中位数为452细胞/ mm（3），高于无应答者（359细胞/ mm（3））。无反应者的HIV血浆病毒载量较高。我们得出的结论是，在接受HAART治疗的HIV-1感染者中，总T CD4细胞计数，记忆T CD4 +细胞和较低的血浆病毒载量可用于预测对乙肝疫苗接种的免疫反应。因此，考虑到成本效益，应优先向HIV感染的T CD4细胞计数超过450细胞/ mm 3的患者提供疫苗接种（3），优先控制HIV复制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号