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首页> 外文期刊>Vaccine >Mucosal immune responses to meningococcal C polysaccharide-protein conjugate in mice
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Mucosal immune responses to meningococcal C polysaccharide-protein conjugate in mice

机译：对小鼠脑膜炎球菌C多糖-蛋白结合物的粘膜免疫反应

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摘要

Mucosal delivery of vaccines represents an attractive approach because this is a region of first contact point for inhaled antigens. We have obtained a meningococcal group C polysaccharide-tetanus toxoid conjugate (MGCP-TT) and evaluated it for intranasal route in mice. The conjugate was obtained by a developed method in our laboratory. The specific IgA in saliva and specific IgA and IgG in serum were measured by ELISA methods and bactericidal antibodies in sera against a meningococcal group C strain were measured. The conjugated elicited a significant increase in anti-MGCP salivary IgA and serum IgG and bactericidal antibodies concentrations, while specific serum IgA was not observed. These results indicated that after conjugation, there was a change in the responses for MGCP from thymus-independent to thymus-dependent and that it was effective by intranasal route.
机译：疫苗的粘膜递送代表了一种有吸引力的方法，因为这是吸入抗原的第一个接触点区域。我们已经获得了脑膜炎球菌C组多糖-破伤风类毒素缀合物（MGCP-TT），并对其在小鼠中的鼻内途径进行了评估。该缀合物通过我们实验室中的发达方法获得。通过ELISA方法测量唾液中的特异性IgA以及血清中的特异性IgA和IgG，并且测量针对脑膜炎球菌C组菌株的血清中的杀菌抗体。结合物引起抗MGCP唾液IgA和血清IgG和杀菌抗体浓度的显着增加，而未观察到特异性血清IgA。这些结果表明，结合后，MGCP的应答从不依赖胸腺变为依赖胸腺，并且通过鼻内途径有效。

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