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首页> 外文期刊>Vaccine >Comparison of the human immune response to conjugate and polysaccharide pneumococcal vaccination using a reconstituted SCID mouse model
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Comparison of the human immune response to conjugate and polysaccharide pneumococcal vaccination using a reconstituted SCID mouse model

机译：使用重组SCID小鼠模型比较人对缀合物和多糖肺炎球菌疫苗的免疫应答

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摘要

The pneumococcal conjugate vaccine (CV), although highly immunogenic in infants and young children, does not consistently demonstrate an advantage over the pneumococcal polysaccharide vaccine (PPV) in older adults. To further elucidate the adult immune response to CV, we compared its response to PPV on a molecular level using a severe combined immunodeficient (SCID) mouse model. This model allowed us to analyze a single individual's response to two different forms of antigen and define differences in gene usage elicited by these vaccines. We reconstituted SCID mice with human lymphocytes derived from an unimmunized donor; the mice were divided into two groups and immunized with either the PPV or CV. Our results demonstrate significant differences in variable gene usage in SCID mice immunized with PPV versus CV and suggest that the nature of the immunizing agent has a significant impact on gene usage and therefore influences antibody function and vaccine efficacy.
机译：肺炎球菌结合疫苗（CV）虽然在婴幼儿中具有高度免疫原性，但在老年人中并未始终显示出优于肺炎球菌多糖疫苗（PPV）的优势。为了进一步阐明成人对CV的免疫反应，我们使用严重的联合免疫缺陷（SCID）小鼠模型在分子水平上比较了其对PPV的反应。该模型使我们能够分析单个人对两种不同形式抗原的反应，并定义这些疫苗引起的基因使用差异。我们用源自未免疫供体的人淋巴细胞重建了SCID小鼠。将小鼠分成两组并用PPV或CV免疫。我们的结果表明，用PPV和CV免疫的SCID小鼠在可变基因使用方面存在显着差异，并表明免疫剂的性质对基因使用具有重大影响，因此会影响抗体功能和疫苗效力。

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