Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

Klein NP; Holmes TH; Sharp MA; Heineman TC; Schleiss MR; Bernstein DI; Kemble G; Arvin AM; Dekker CL

首页> 外文期刊>Vaccine >Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

【24h】

Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

机译：健康成年人对水痘带状疱疹病毒的记忆T细胞免疫力的变异性和性别差异

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p<0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p<0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.

机译：水痘潜伏性带状疱疹病毒（VZV）可以重新激活并引起带状疱疹，其预防取决于对VZV的细胞免疫。为了评估健康自然免疫成年人中VZV细胞介导的免疫的时间变化，我们在25个成年人中的每一个成年人中纵向评估了VZV特异性应答细胞频率（RCF）超过1年。检测到VZV特异性CD4 + T细胞（p <0.003），并且RCF的变异性最小。对VZV T细胞RCF的其他分析显示，性别之间存在差异，只有男性（p <0.005）通过这种方法具有可检测到的VZV特异性记忆CD4 + T细胞应答。两者合计，结果表明，可能需要进行进一步的研究，以改良的，高效能的减毒活VZV疫苗对年轻人和女性进行免疫。

著录项

来源
《Vaccine》 |2006年第34期|共6页
作者
Klein NP; Holmes TH; Sharp MA; Heineman TC; Schleiss MR; Bernstein DI; Kemble G; Arvin AM; Dekker CL;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词

相似文献

外文文献
中文文献
专利

1. Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults [J] . Klein NP, Holmes TH, Sharp MA, Vaccine . 2006,第33a34期

机译：健康成年人对水痘带状疱疹病毒的记忆T细胞免疫力的变异性和性别差异
2. Age-related differences in cell-mediated immunity to varicella-zoster virus among children and adults immunized with live attenuated varicella vaccine. [J] . Nader S, Bergen R, Sharp M, The Journal of Infectious Diseases . 1995,第1期

机译：水痘减毒活疫苗免疫的儿童和成年人中，细胞介导的对水痘带状疱疹病毒免疫力的年龄相关差异。
3. Genomic cartography of varicella-zoster virus: A complete genome-based analysis of strain variability with implications for attenuation and phenotypic differences [J] . Tyler SD, Peters GA, Grose C, Virology . 2007,第2期

机译：水痘带状疱疹病毒的基因组制图：基于全基因组的菌株变异性分析，对减毒和表型差异具有影响
4. GENDER DIFFERENCES IN THE VARIABILITY OF GAIT IN HEALTHY SUBJECTS [C] . Rita M. Kiss Biomedical engineering . 2012

机译：健康受试者步态变异的性别差异
5. Setting the Stage for a Potential Varicella-Zoster Virus (VZV)-Based HIV Vaccine: Characterization of the Mucosal Immune Response Induced by VZV Vaccination in Humans [D] . Perciani, Catia Taniela. 2019

机译：为潜在的水痘 - 带状疱疹病毒（VZV）的阶段为基础的HIV疫苗：在人类中vzV疫苗接种诱导的粘膜免疫应答的表征
6. Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection [O] . Jeffy George, Ryan C. Johnson, Mary J. Mattapallil, 2012

机译：记忆猿猴免疫缺陷病毒感染的早期阶段，记忆CD4 T细胞的先天应答和基因表达谱存在性别差异。
7. Focal Encephalitis Following Varicella-Zoster Virus Reactivation Without Rash in a Healthy Immunized Young Adult [O] . Geoffrey Halling, Caterina Giannini, Jeffrey W. Britton, 2014

机译：局灶性脑炎术后 - 群叶病毒重新激活，没有皮疹在健康免疫的年轻成年中

Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

摘要

著录项

相似文献

相关主题

期刊订阅