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首页> 外文期刊>Vaccine >Hospital-based active surveillance of childhood pertussis in Austria from 1996 to 2003: Estimates of incidence and vaccine effectiveness of whole-cell and acellular vaccine
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Hospital-based active surveillance of childhood pertussis in Austria from 1996 to 2003: Estimates of incidence and vaccine effectiveness of whole-cell and acellular vaccine

机译：1996年至2003年奥地利基于医院的儿童百日咳百日咳的积极监测：全细胞和脱细胞疫苗的发病率和疫苗效力估算

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BACKGROUND: This study was undertaken to analyse the epidemiology of pertussis disease among hospitalised children during the transition period from whole-cell to acellular pertussis vaccine in order to compare the respective estimates of vaccine effectiveness. METHODS: Surveillance was conducted between 1 January 1996 and 31 December 2003. The data originated from a voluntary hospital-based surveillance network including all 44 nationwide paediatric departments. RESULTS: The mean annual hospitalisation incidence for children decreased over time, from 27.9 per 100000 population in 1996 to 6.8 cases per 100000 population in 2003. The mean age of reported hospitalised pertussis cases was 4.7 years (+/-5.5 S.D.), increasing from 4.06 years (+/-4.6 S.D.) in 1996 to 5.5 years (+/-8.6 S.D.) in 2003. Estimated vaccine effectiveness (after three vaccine doses) was 79% for the whole-cell versus 92% for the acellular pertussis vaccine. A significantly higher proportion (19%) of fully immunised children among hospitalised patients was observed for the years where only acellular pertussis vaccine was used compared to whole-cell vaccine era (2%) which was, however, mainly due to children above 2 years of age. CONCLUSIONS: Our results imply that despite high vaccination coverage rate, pertussis is still a considerable cause of hospital admissions in children in Austria where it remains to be shown that the novel vaccination strategy of additional booster doses in adolescents and adults will control disease in the long term.
机译：背景：本研究旨在分析住院儿童从全细胞百日咳疫苗到无细胞百日咳疫苗过渡期的百日咳疾病流行病学，以比较各自疫苗效力的估计。方法：在1996年1月1日至2003年12月31日期间进行了监测。数据来源于一个自愿的，基于医院的监测网络，包括全国所有44个儿科部门。结果：儿童的年平均住院率随着时间的推移而下降，从1996年的每100000人口27.9例下降到2003年的每100000人口6.8例。报告的住院百日咳病例的平均年龄为4.7岁（+/- 5.5 SD），从从1996年的4.06年（+/- 4.6 SD）到2003年的5.5年（+/- 8.6 SD）。全细胞的估计疫苗有效性（三剂疫苗后）为79％，而脱细胞百日咳疫苗为92％。与全细胞疫苗时代（2％）相比，仅使用无细胞百日咳疫苗的年份中，住院患者中完全免疫儿童的比例显着较高（19％），这主要是由于2岁以上的儿童年龄。结论：我们的结果表明，尽管疫苗接种率很高，但百日咳仍是奥地利儿童住院的重要原因，仍有待证明，青少年和成人增加疫苗剂量的新颖疫苗接种策略将长期控制疾病术语。

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