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首页> 外文期刊>Vaccine >Interchangeability of Hepatitis A boosters, Avaxim and Vaqta, in healthy adults following a primary dose of the combined typhoid/Hepatitis A vaccine Viatim
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Interchangeability of Hepatitis A boosters, Avaxim and Vaqta, in healthy adults following a primary dose of the combined typhoid/Hepatitis A vaccine Viatim

机译：初次服用伤寒/甲型肝炎联合疫苗Viatim后，健康成年人中甲型肝炎增强剂Avaxim和Vaqta的互换性

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摘要

This study investigated the suitability of Avaxim and Vaqta as Hepatitis A booster vaccines 6 months after priming with the combined Hepatitis A/typhoid vaccine, Viatim. One hundred and twenty adults were randomly assigned to one of the three groups. Group A (reference group) received Avaxim then Avaxim (n = 40), Group B received Viatim then Avaxim (n = 41) and Group C received Viatim then Vaqta (n = 39). One month after booster vaccination, anti-Hepatitis A virus (anti-HAV) antibodies geometric mean concentrations (GMC) of subjects primed with Viatim were non-inferior to the group primed and boosted with the monovalent Hepatitis A vaccine Avaxim. Anti-Salmonella typhi capsular polysaccharide virulence antigen (anti-Vi) GMCs in groups primed with Viatim were protective and all vaccines were well-tolerated. Therefore, Viatim may be used as a primary HAV vaccine with either Avaxim or Vaqta as Hepatitis A boosters and it will provide the same protection as two doses of Avaxim.
机译：这项研究调查了Avaxim和Vaqta作为A型肝炎加强疫苗与A型/伤寒联合疫苗Viatim一起接种后的适用性。一百二十名成年人被随机分配到三组中的一组中。 A组（参考组）先接受Avaxim，然后再使用Avaxim（n = 40），B组先接受Viatim，然后再进行Avaxim（n = 41），C组先接受Viatim，然后再接受Vaqta（n = 39）。加强免疫后一个月，接受Viatim免疫的受试者的抗A型肝炎病毒（抗HAV）抗体的几何平均浓度（GMC）不逊于通过单价A肝炎疫苗Avaxim进行初治和增强的人群。用Viatim引发的组中的鼠伤寒伤寒沙门氏菌荚膜多糖毒力抗原（anti-Vi）GMC具有保护性，所有疫苗均耐受良好。因此，Viatim可以与Avaxim或Vaqta一起用作甲型肝炎的增强剂，作为主要的HAV疫苗，它将提供与两剂Avaxim相同的保护作用。

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