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How bacteria and their products provide clues to vaccine and adjuvant development

机译:细菌及其产品如何为疫苗和佐剂开发提供线索

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摘要

Evidence has emerged that both vertebrates and invertebrates share innate immune pathways involved in the recognition of and the response to micro-organisms, including bacteria and their products. As a consequence, particular degenerate products of bacteria can stimulate and modulate immune responses and influence acquired immunity and, potentially, protection against disease. New knowledge in this field is beginning to explain how vaccine adjuvants work and will facilitate the future development of novel adjuvants and vaccines.
机译:已有证据表明,脊椎动物和无脊椎动物都共享与识别和响应微生物(包括细菌及其产物)有关的先天免疫途径。结果,特定的简并细菌产物可以刺激和调节免疫应答并影响获得的免疫力,并可能保护其免受疾病侵害。该领域的新知识开始解释疫苗佐剂的工作原理,并将促进新型佐剂和疫苗的未来发展。

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