A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma

Kaplan CD; Kruger JA; Zhou H; Luo Y; Xiang R; Reisfeld RA

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A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma

机译：编码PDGFRbeta的新型DNA疫苗可抑制鼠结肠癌，肺癌和乳腺癌的生长和扩散

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Over the past several years it has become apparent that the tumor stroma represents a significant target for anti-cancer therapies. Therefore we evaluated the strategy of targeting the tumor stroma with a novel DNA vaccine encoding murine platelet derived growth factor receptor-beta (mPDGFRbeta). Immunization with this vaccine induced cytotoxic lysis of mPDGFRbeta-expressing target cells and protected mice from the growth and dissemination of murine colon, breast and lung carcinoma. Furthermore, this novel vaccine suppresses angiogenesis in vivo and reduces the numbers of tumor-associated, mPDGFRbeta-expressing pericytes as suggested by a decrease in intra-tumoral expression of mPDGFRbeta and NG2.

机译：在过去的几年中，很明显，肿瘤基质代表了抗癌治疗的重要目标。因此，我们评估了用编码鼠血小板衍生的生长因子受体-β（mPDGFRbeta）的新型DNA疫苗靶向肿瘤基质的策略。用这种疫苗免疫可诱导表达mPDGFRβ的靶细胞发生细胞毒性裂解，并保护小鼠免受鼠结肠癌，乳腺癌和肺癌的生长和扩散。此外，这种新型疫苗在体内抑制血管生成，并减少了肿瘤相关的表达mPDGFRbeta的周细胞的数量，这是由于mPDGFRbeta和NG2的肿瘤内表达减少所暗示的。

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来源
《Vaccine》 |2006年第48期|共9页
作者
Kaplan CD; Kruger JA; Zhou H; Luo Y; Xiang R; Reisfeld RA;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Administration; Oral; Animals; Blotting; Western; Cancer Vaccines immunology; Cell Line; Tumor; Cell Survival immunology; Colonic Neoplasms immunology pathology therapy; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Lung Neoplasms immunology pathology therapy; Mammary Neoplasms; Animal immunology pathology therapy; Mice; Mice; Inbred BALB C; Mice; Inbred C57BL; Neoplasm Transplantation immunology; Neovascularization; Pathologic immunology pathology prevention amp; control; Receptor; Platelet-Derived Growth Factor beta immunology; Vaccination; Vaccines; DNA immunology;

机译：给药;口服;动物;印迹;西方;癌症疫苗免疫;细胞系;肿瘤;细胞存活免疫;结肠肿瘤免疫病理疗法;酶联免疫吸附测定;女性;流式细胞术;肺肿瘤免疫病理疗法;乳腺肿瘤;动物免疫病理病理疗法;小鼠;小鼠;近交BALB C;小鼠;近交C57BL;肿瘤移植免疫学;新生血管形成;病理学免疫病理学预防和控制;受体;血小板衍生生长因子β免疫学;疫苗接种;疫苗;DNA免疫学;

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专利

1. A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma [J] . Kaplan CD, Kruger JA, Zhou H, Vaccine . 2006,第47a48期

机译：编码PDGFRbeta的新型DNA疫苗可抑制鼠结肠癌，肺癌和乳腺癌的生长和扩散
2. DNA Vaccine Encoding α-Fetoprotein Fused with the Ornithine Decarboxylase Degradation Signal Significantly Suppresses the Hepatocellular Carcinoma Growth in Mice [J] . A. V. Morozov, V. A. Morozov, T. M. Astakhova Molecular Biology . 2012,第3期

机译：鸟氨酸脱羧酶降解信号融合的编码α-甲胎蛋白的DNA疫苗显着抑制小鼠肝细胞癌的生长。
3. Particle-mediated gene transfer of murine interleukin-12 cDNA suppresses the growth of Lewis lung carcinoma. [J] . Oshikawa K, Ishii Y, Hamamoto T, In vivo. . 1999,第5期

机译：小鼠白介素-12 cDNA的粒子介导的基因转移抑制了Lewis肺癌的生长。
4. Comparative study between BD Falcon#x00AE; and Corning#x00AE; cell culture flask on viability and growth of breast, colon, liver and lung cancer cell lines [C] . Afiqah M. A. Nurul, Haikal Z. Izmil, Zolkapli E., 2012 IEEE Symposium on Business, Engineering and Industrial Applications. . 2012

机译：BDFalcon®和Corning®细胞培养瓶对乳腺癌，结肠癌，肝癌和肺癌细胞系活力和生长的比较研究
5. Apoptosis of breast and colon carcinoma cells by inhibitors of glycolipid and DNA biosynthesis. [D] . Ma, Rui. 2008

机译：糖脂和DNA生物合成抑制剂可抑制乳腺癌和结肠癌细胞的凋亡。
6. Post-operative unadjuvanted therapeutic xenovaccination with chicken whole embryo vaccine suppresses distant micrometastases and prolongs survival in a murine Lewis lung carcinoma model [O] . Jan Aleksander Kraśko, Karolina Žilionytė, Adas Darinskas, -1

机译：鸡全胚疫苗的术后无辅助治疗性异种疫苗接种可抑制小鼠Lewis肺癌模型中的微小转移并延长生存期
7. Co-administration of a DNA vaccine encoding the prostate specific membrane antigen and CpG oligodeoxynucleotides suppresses tumor growth [O] . 2004

机译：共同施用编码前列腺特异性膜抗原和CpG寡脱氧核苷酸的DNA疫苗可抑制肿瘤生长
8. Blocking Blood Supply to Breast Carcinoma With a DNA Vaccine Encoding VEGF Receptor-2 [R] . Zhou, H. , Luo, Y. , Kaplan, C. D. , 2006

机译：用编码VEGF受体-2的DNa疫苗阻断乳腺癌的血液供应

A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma

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