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首页> 外文期刊>Vaccine >Protective effect of Bacillus Calmette-Guerin (BCG) vaccination in children with extra-pulmonary tuberculosis, but not the pulmonary disease A case-control study in Rosario, Argentina
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Protective effect of Bacillus Calmette-Guerin (BCG) vaccination in children with extra-pulmonary tuberculosis, but not the pulmonary disease A case-control study in Rosario, Argentina

机译：卡介苗芽孢杆菌（BCG）疫苗接种对肺外结核儿童的保护作用，但对肺部疾病没有保护作用阿根廷罗萨里奥的病例对照研究

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A hospital-based case-control study was carried out at the Vilela Children's Hospital in Rosario, Argentina, to measure the protection conferred by BCG vaccination against tuberculosis (TB). The study included 148 newly diagnosed cases of TB (75 males and 73 females, mean age 3.34+/-2.97 years, S.D.), 134 of them with pulmonary TB and 14 cases with extra-pulmonary disease. Controls (425 males and 357 females, 3.39+/-2.98 years) were selected randomly among children who attended to the Hospital showing, neither respiratory diseases nor any other infectious illnesses. Information on BCG vaccination history was assessed from scars or immunisation records. All participants were negative to human immunodeficiency virus and belonged to the lower and upper-lower socioeconomic status, being similar in place of residence and ethnic characteristics. Rate of vaccinated children was 92.6% of cases and 94.5% of controls (3.4 and 3.9% of them without scars, respectively). Regarding the total cases, the protective association between BCG and TB was statistically insignificant, as was for the pulmonary form. Among cases with extra-pulmonary disease, vaccine effectiveness attained significance [79% (95% CI=26-94)], no matter their age, sex or nutritional status. BCG vaccination exerted a beneficial role in extra-pulmonary TB, even in children not seriously undernourished.
机译：在阿根廷罗萨里奥的维莱拉儿童医院进行了一项基于医院的病例对照研究，以评估卡介苗接种对结核病的保护作用。该研究包括148例新诊断的TB病例（男性75例，女性73例，平均年龄为3.34 +/- 2.97岁，S.D。），其中134例患有肺结核，另外14例患有肺外疾病。在就诊时未发现呼吸道疾病或任何其他传染病的儿童中随机选择对照组（男性425例，女性357例，年龄3.39 +/- 2.98岁）。从伤疤或免疫记录中评估了BCG疫苗接种史的信息。所有参与者均对人类免疫缺陷病毒阴性，并且属于较低和较高的社会经济地位，在居住地点和种族特征方面相似。接种儿童的比例为病例的92.6％和对照组的94.5％（分别为3.4％和3.9％无疤痕）。对于总病例，BCG和TB之间的保护性关联在统计学上不显着，肺部形式也是如此。在患有肺外疾病的病例中，无论年龄，性别或营养状况如何，疫苗有效性均达到显着水平[79％（95％CI = 26-94）]。 BCG疫苗接种在肺外结核中发挥了有益的作用，即使在营养不良严重的儿童中也是如此。

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