Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA

Zuber AK; Brave A; Engstrom G; Zuber B; Ljungberg K; Fredriksson M

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Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA

机译：将咪喹莫特局部递送至小鼠模型作为人类免疫缺陷病毒（HIV）DNA的新型佐剂

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We evaluated the compound imiquimod as a possible adjuvant for DNA immunization against human immunodeficiency virus (HIV). We found that gene-gun epidermal delivery of the DNA in combination with imiquimod resulted in the strongest HIV specific immune responses. The effect of imiquimod was further compared to that of recombinant granulocyte macrophage-colony stimulating factor (GM-CSF), a known DNA vaccine adjuvant. Both adjuvants were able to enhance the immune responses induced by the HIV-1 genes alone. The delivery of an adjuvant as a topical cream rather than through injections has a clear clinical benefit. We show for the first time that imiquimod can act as an adjuvant for DNA vaccination

机译：我们评估了化合物咪喹莫特作为抗人免疫缺陷病毒（HIV）的DNA免疫的可能佐剂。我们发现与咪喹莫特组合使用的基因枪表皮传递的DNA导致最强的HIV特异性免疫反应。将咪喹莫特的作用与已知的DNA疫苗佐剂重组粒细胞巨噬细胞集落刺激因子（GM-CSF）进行了比较。两种佐剂均能够增强仅由HIV-1基因诱导的免疫应答。佐剂作为局部乳膏而不是通过注射给药具有明显的临床益处。我们首次证明咪喹莫特可以作为DNA疫苗的佐剂

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《Vaccine》 |2004年第14期|共8页
作者
Zuber AK; Brave A; Engstrom G; Zuber B; Ljungberg K; Fredriksson M;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Imiquimod; Dna vaccination; Hiv-1; Gm-csf; Immune-responses; Vaccine; Cells; Antigen; Genes; Immunization; Resistance; Challenge; Induction; Epitopes;

机译：咪喹莫特;Dna疫苗接种;Hiv-1;Gm-csf;免疫反应;疫苗;细胞;抗原;基因;免疫;抗性;挑战;诱导;表位;

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1. Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA [J] . Zuber AK, Brave A, Engstrom G, Vaccine . 2004,第13a14期

机译：将咪喹莫特局部递送至小鼠模型作为人类免疫缺陷病毒（HIV）DNA的新型佐剂
2. Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1. [J] . Lascaux AS, Caumes E, Deback C, Journal of Medical Virology . 2012,第2期

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3. Human Immunodeficiency Virus (HIV) Quality Indicators Are Similar Across HIV Care Delivery Models [J] . Virginia A. Triant, Corinne M. Rhodes, Susan Regan, Open Forum Infectious Diseases . 2017,第1期

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5. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

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机译：人类免疫缺陷病毒（HIV）质量指标在HIV护理提供模型中相似
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Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA

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