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首页> 外文期刊>Vox Sanguinis: International Journal of Blood Transfusion and Immunohaematology >Significant background rates of HBV and HCV infections in patients and risks of blood transfusion from donors with low anti-HBc titres or high anti-HBc titres with high anti-HBs titres in Japan: A prospective, individual NAT study of transfusion-transmitted HBV, HCV and HIV infections
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Significant background rates of HBV and HCV infections in patients and risks of blood transfusion from donors with low anti-HBc titres or high anti-HBc titres with high anti-HBs titres in Japan: A prospective, individual NAT study of transfusion-transmitted HBV, HCV and HIV infections

机译：在日本，患者的HBV和HCV感染的显着背景发生率以及来自抗HBc效价低或抗HBs效价高的抗HBc效价高的供体的输血风险：一项通过输血传播的HBV的前瞻性，单独NAT研究， HCV和HIV感染

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Background The Japanese Red Cross (JRC) conducted a prospective study to evaluate the frequency of transfusion-transmitted HBV, HCV and HIV infections to assess the risk of transfusion of blood components routinely supplied to hospitals. Study Design and Methods Post-transfusion specimens from patients at eight medical institutes were examined for evidence of infection with HBV (2139 cases), HCV (2091) and HIV (2040) using individual nucleic acid amplification testing (NAT). If these specimens were reactive, pre-transfusion specimens were also examined for the virus concerned by individual NAT. In the event that the pre-transfusion specimen was non-reactive, then all repository specimens from implicated donors were tested for the viruses by individual donation NAT. In addition, a further study was carried out to evaluate the risk of transfusion of components from donors with low anti-HBc titres or high anti-HBc with high anti-HBs titres. Results Transfusion-transmitted HCV and HIV infections were not observed. One case of post-transfusion HBV infection was identified (rate, 0·0004675; 95% CI for the risk of transmission, 1 in 451-41841). The background rates of HBV, HCV and HIV infections in patients prior to transfusion were 3·4% (72/2139), 7·2% (150/2091) and 0% (0/2040), respectively. Sixty-four anti-HBc- and/or anti-HBs-reactive blood components were transfused to 52 patients non-reactive for anti-HBc or anti-HBs before and after transfusion (rate, 0; 95% CI for the risk of transmission, <1 in 22). Conclusion This study demonstrated that the current criteria employed by JRC have a low risk, but the background rates of HBV and HCV infections in Japanese patients are significant.
机译：背景技术日本红十字会（JRC）进行了一项前瞻性研究，以评估输血传播的HBV，HCV和HIV感染的频率，以评估常规提供给医院的血液成分输血的风险。研究设计和方法使用单个核酸扩增测试（NAT）检查了来自八家医疗机构患者的输血后标本，以检查是否感染了HBV（2139例），HCV（2091）和HIV（2040）。如果这些样本具有反应性，则还应通过单独的NAT检查输血前样本中有关病毒。如果输血前样本没有反应性，则通过单独的捐赠NAT对所有来自牵连供体的储存库样本进行病毒检测。此外，还进行了进一步的研究，以评估抗-HBc滴度低或抗-HBs滴度高的抗-HBc供体输注成分的风险。结果未观察到输血传播的HCV和HIV感染。确认了1例输血后HBV感染（发生率为0·0004675; 95％CI为传播风险，在451-41841中为1）。输血前患者的HBV，HCV和HIV感染本底率分别为3·4％（72/2139），7·2％（150/2091）和0％（0/2040）。向在输注前后对抗HBc或抗HBs无反应的52例患者中输注了64种抗HBc和/或抗HBs反应性血液成分（比率为0;传播风险为95％CI） ，<1 in 22）。结论该研究表明，JRC目前采用的标准具有较低的风险，但日本患者的HBV和HCV感染本底率很高。

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