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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes
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DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

机译：DNA结合药物发挥作用：药物-DNA复合物的最新3D图片

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摘要

In this paper, we review recent DNA-binding agents that are expected to influence the field of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure in complex with DNA or RNA has been determined by X-ray crystallography or NMR. Furthermore, we primarily focus on unprecedented ways of targeting peculiar DNA structures, such as junctions, quadruplexes, and duplex DNAs different from the B-form. Classical binding modes of small molecular weight compounds to DNA, i.e. groove binding, intercalation and covalent addition are discussed in those cases where the structures represent a novelty. In addition, we review 3D structures of triple-stranded DNA, of the so-called Peptide Nucleic Acids (PNAs), which are oligonucleotide bases linked by a polypeptide backbone, and of aptamers, which are DNA or RNA receptors that are designed combinatorially. A discussion on perspectives in the field of DNA-targeting and on sequence recognition is also provided.
机译：在本文中，我们综述了预期会影响DNA靶向领域的最新DNA结合剂。我们将自己限制在通过X射线晶体学或NMR确定与DNA或RNA复杂的三维结构的粘合剂。此外，我们主要关注针对B形式不同的特殊DNA结构（如连接，四链体和双链体DNA）的空前方式。在结构代表新颖性的情况下，讨论了小分子量化合物与DNA的经典结合方式，即凹槽结合，嵌入和共价添加。此外，我们回顾了三链DNA的3D结构，所谓的肽核酸（PNA）和适体，所述3D结构是通过多肽主链连接的寡核苷酸碱基，而适体是组合设计的DNA或RNA受体。还提供了有关DNA靶向领域的观点和序列识别的讨论。

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