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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity
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The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity

机译：具有异常高细胞毒性的反式铂（iv）复合物的制备和表征

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The physical and biological properties have been determined for three Pt(iv) complexes with trans amine ligands: trans,trans,trans-[PtCl l_2(OH)_2(dimethylamine)(isopropylamine)] (1~(IV)), trans,trans,trans-[PtCl_2(OH)_2(dimethylamine)(methylamine)] (2~(IV)) and trans,trans,trans-[PtCl_2(OH) _2(isopropylamine)(methylamine)] (3~(IV)). The crystal structures of 2~(IV) and 3~(IV) reveal substantial strain resulting from repulsion between the amine ligands and the chlorido and hydroxido ligands. All three complexes have reduction potentials in the range -666 to -770 mV, values usually associated with high resistance to reduction and low cytotoxicity. However, the complexes all demonstrate surprisingly high cytotoxicity with values and trends that closely follow those seen for the Pt(ii) congeners of these complexes. These results are consistent with more rapid reduction of the Pt(iv) complexes than would be expected based on the reduction potentials, perhaps associated with the trans arrangement of the chlorido ligands.
机译：已确定了具有反胺配体的三种Pt（iv）配合物的物理和生物学特性：反式，反式，反式-[PtCl 12_2（OH）_2（二甲胺）（异丙胺）]（1〜（IV）），反式，反式，反式-[PtCl_2（OH）_2（二甲胺）（甲胺）]（2〜（IV））和反式，反式，反式-[PtCl_2（OH）_2（异丙胺）（甲胺）] ）。 2〜（IV）和3〜（IV）的晶体结构显示出很大的应变，这是由于胺配体与氯代和羟基配体之间的排斥而引起的。所有这三种复合物的还原电位都在-666至-770 mV的范围内，通常与高抗还原性和低细胞毒性有关。然而，这些复合物均表现出令人惊讶的高细胞毒性，其值和趋势与这些复合物的Pt（ii）同系物所观察到的密切相关。这些结果与Pt（iv）络合物的还原相比比基于还原电位所预期的更快的还原相一致，这可能与氯配体的反式排列有关。

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