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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Methoxy-substituted isoTQEN family for enhanced fluorescence response toward zinc ion
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Methoxy-substituted isoTQEN family for enhanced fluorescence response toward zinc ion

机译：甲氧基取代的isoTQEN家族可增强对锌离子的荧光响应

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Previously, we have reported that 1- and 3-isoTQENs (N,N,N′,N′- tetrakis(1- or 3-isoquinolylmethyl)ethylenediamines) exhibit a specific fluorescence enhancement toward zinc ion. In this study, three methoxy-substituted derivatives of 1-isoTQEN were synthesized and their fluorescent response toward zinc ion was studied. The substitution pattern of the methoxy group significantly changes the solubility of compounds in aqueous DMF, λ_(max) in the absorption spectra, excitation/emission wavelengths and fluorescence intensity of zinc complexes. In the presence of zinc ion, 7-MeO-1-isoTQEN exhibits higher fluorescence intensity and longer excitation/emission wavelengths (λ_(ex) = 342 nm, λ_(em) = 526 nm) than 6-MeO-1-isoTQEN (λ_(ex) = 303 nm, λ_(em) = 469 nm) and 5,6,7-triMeO-1-isoTQEN (λ_(ex) = 340 nm, λ_(em) = 504 nm). The fluorescence intensity of a zinc complex of 7-MeO-1-isoTQEN (= 0.122) is four times higher than the parent 1-isoTQEN (= 0.034) under the same conditions. The crystal structure of 7-MeO-1-isoTQEN-Zn complex reveals that all six nitrogen atoms participate to the metal coordination with ideal octahedral geometry, affording significantly high metal binding affinity comparable with TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine). 7-MeO-1-isoTQEN detects zinc ion concentration change in cells by fluorescence microscopic analysis.
机译：以前，我们已经报道过1-和3-isoTQENs（N，N，N'，N'-四（1-或3-异喹啉基甲基）乙二胺）对锌离子表现出特定的荧光增强作用。在这项研究中，合成了1-isoTQEN的三个甲氧基取代的衍生物，并研究了它们对锌离子的荧光响应。甲氧基的取代方式显着改变了化合物在DMF水溶液中的溶解度，吸收光谱，激发/发射波长和锌络合物的荧光强度的λ_（max）。在存在锌离子的情况下，7-MeO-1-isoTQEN比6-MeO-1-isoTQEN具有更高的荧光强度和更长的激发/发射波长（λ_（ex）= 342 nm，λ_（em）= 526 nm）（ λ_（ex）= 303 nm，λ_（em）= 469 nm）和5,6,7-triMeO-1-isoTQEN（λ_（ex）= 340 nm，λ_（em）= 504 nm）。在相同条件下，7-MeO-1-isoTQEN（= 0.122）的锌配合物的荧光强度是母体1-isoTQEN（= 0.034）的四倍。 7-MeO-1-isoTQEN-Zn配合物的晶体结构表明，所有六个氮原子均以理想的八面体几何形状参与金属配位，与TPEN（N，N，N'，N'-四（2-吡啶基甲基）乙二胺）。 7-MeO-1-isoTQEN通过荧光显微镜分析检测细胞中锌离子浓度的变化。

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