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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands
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Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands

机译：席夫碱衍生香豆素配体的铜（II）配合物的生物活性和配位模式

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摘要

The coordination modes of copper(ii) complexes of Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the coordination mode of the ligands to be through the N of the imine and deprotonated phenol of the coumarin-derived ligand in solution. In addition, the more active complexes and their corresponding ligands were investigated in the presence of copper(ii) in liquid and frozen solution by ESR spectroscopic methods. A series of secondary amine derivatives of the Schiff base ligands, were isolated with good solubility characteristics but showed little anti-Candida activity. However, cytotoxicity studies of the secondary amines, together with the copper complexes and their corresponding ligands, against human colon cancer and human breast cancer cells identified the chemotherapeutic potential of these new ligands.
机译：通过pH电位法和UV-Vis光谱法研究了席夫碱衍生的香豆素配体的铜（ii）配合物的配位模式，该配体以前显示出良好的抗念珠菌活性。这些研究证实了配体的配位模式是通过溶液中香豆素衍生的配体的亚胺的N和去质子化的酚。此外，通过ESR光谱方法在液体和冷冻溶液中存在铜（ii）的情况下研究了更具活性的配合物及其相应的配体。分离了具有席夫碱配体的一系列仲胺衍生物，具有良好的溶解性，但几乎没有抗念珠菌活性。但是，仲胺与铜配合物及其相应配体对人结肠癌和乳腺癌细胞的细胞毒性研究确定了这些新配体的化学治疗潜力。

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