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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Non-steroidal antiinflammatory drug-copper(II) complexes: Structure and biological perspectives
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Non-steroidal antiinflammatory drug-copper(II) complexes: Structure and biological perspectives

机译：非甾体类抗炎药铜（II）复合物：结构和生物学观点。

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Copper(ii) complexes with the non-steroidal antiinflammatory drug mefenamic acid in the presence of aqua or nitrogen donor heterocyclic ligands (2,2′-bipyridine, 1,10-phenanthroline, 2,2′-bipyridylamine or pyridine) have been synthesized and characterized. The crystal structures of [(2,2′-bipyridine)bis(mefenamato)copper(ii)], 2, [(2,2′- bipyridylamine)bis(mefenamato)copper(ii)], 4, and [bis(pyridine)bis(methanol) bis(mefenamato)copper(ii)], 5, have been determined by X-ray crystallography. UV study of the interaction of the complexes with calf-thymus DNA (CT DNA) has shown that the complexes can bind to CT DNA and [bis(aqua)tetrakis(mefenamato) dicopper(ii)] exhibits the highest binding constant to CT DNA. The cyclic voltammograms of the complexes in the presence of CT DNA solution have shown that the complexes can bind to CT DNA by the intercalative binding mode verified also by DNA solution viscosity measurements. Competitive studies with ethidium bromide (EB) indicate that the complexes can displace the DNA-bound EB suggesting strong competition with EB. Mefenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values. All the compounds have been tested for their antioxidant and free radical scavenging activity as well as for their in vitro inhibitory activity against soybean lipoxygenase showing significant activity.
机译：合成了在水或氮供体杂环配体（2,2'-联吡啶，1,10-菲咯啉，2,2'-联吡啶胺或吡啶）存在下与非甾体抗炎药甲芬那酸铜（ii）配合物和特点。 [[（2,2'-联吡啶）双（苯甲酰氨基）铜（ii）]，2，[[（2,2'-联吡啶胺）双（联苯胺基）铜（ii）]，4和[bis（吡啶）双（甲醇）双（甲酰胺）铜（ii），已通过X射线晶体学测定。配合物与小牛胸腺DNA（CT DNA）相互作用的紫外线研究表明，该配合物可以与CT DNA结合，[双（水）四（甲萘醌）dicopper（ii）]与CT DNA的结合常数最高。在存在CT DNA溶液的情况下，复合物的循环伏安图显示，复合物可以通过嵌入结合模式与CT DNA结合，DNA粘度测量也证明了这种结合。与溴化乙锭（EB）的竞争性研究表明，该复合物可以取代与DNA结合的EB，表明与EB的竞争激烈。甲芬那酸及其络合物对具有相对较高结合常数值的人或牛血清白蛋白具有良好的结合倾向。已测试所有化合物的抗氧化剂和自由基清除活性，以及​​对大豆脂氧合酶的体外抑制活性，这些化合物均显示出显着的活性。

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