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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Selective photothermal therapy for breast cancer with targeting peptide modified gold nanorods
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Selective photothermal therapy for breast cancer with targeting peptide modified gold nanorods

机译:靶向肽修饰的金纳米棒对乳腺癌的选择性光热疗法

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In this work, we prepared polyacrylic acid (PAA) coated gold nanorods (GNRs) and then the targeting peptide modified GNRs. The biocompatibility and stability of functionalized GNRs were investigated by monitoring the surface plasmon resonance (SPR) absorption intensity. The efficacy of targeted thermal therapy can be significantly enhanced via decoration with surface-bound peptide which was obtained through phage display technology. In addition, the photothermal therapy was monitored in real time with the multi-channel function of a confocal laser scanning microscope (CLSM) coupled with an 808 nm laser. This selective photothermal therapy of GNRs is a promising candidate for phototherapeutic applications.
机译:在这项工作中,我们准备了聚丙烯酸(PAA)涂层的金纳米棒(GNR),然后制备了靶向肽修饰的GNR。通过监测表面等离振子共振(SPR)吸收强度来研究功能化GNR的生物相容性和稳定性。通过用噬菌体展示技术获得的表面结合肽进行修饰,可以显着提高靶向热疗法的功效。此外,通过共焦激光扫描显微镜(CLSM)的多通道功能与808 nm激光耦合,可以实时监控光热疗法。 GNR的这种选择性光热疗法是光疗应用的有希望的候选者。

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