Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl_4(DMSO)(Im)], NAMI-A

Mauro Ravera; Sara Baracco; Claudio Cassino; Piero Zanello; Domenico Osella

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Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl_4(DMSO)(Im)], NAMI-A

机译：评价抗转移钌（III）配合物[ImH] [RuCl_4（DMSO）（Im）]，NAMI-A的氧化还原行为

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The imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenate(III) complex [ImH][Ru(III)Cl_4(DMSO)(Im)], NAMI-A, has shown an interesting antimetastatic activity. Since Ru(III) complexes are coordinatively more inert than the corresponding Ru(II) derivatives, an activation by reduction mechanism has been proposed to explain the biological activity of NAMI-A, thus acting as a pro-drug. We report here an electrochemical study on NAMI-A in aqueous solutions which emphasizes the structural and chemical consequences accompanying the easy Ru(III)/Ru(II) electron transfer (e.g., axial imidazole/water exchange in acidic solution in the short timescale of cyclic voltammetry followed by equatorial chloride/water exchange in the longer timescale of macroelectrolysis).

机译：NAMI-A的咪唑鎓反式四氯（二甲基亚砜）咪唑钌酸酯（III）络合物[ImH] [Ru（III）Cl_4（DMSO）（Im）]具有令人感兴趣的抗转移活性。由于Ru（III）配合物比相应的Ru（II）衍生物在活性上更加惰性，因此有人提出通过还原机制激活来解释NAMI-A的生物学活性，从而充当前药。我们在此报告了对水溶液中NAMI-A的电化学研究，该研究强调了伴随着Ru（III）/ Ru（II）电子容易转移的结构和化学后果（例如，在短时间范围内酸性溶液中轴向咪唑/水交换）循环伏安法，然后在较大的时间范围内进行赤道氯化物/水交换）。

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《Dalton transactions: An international journal of inorganic chemistry》 |2004年第15期|共5页
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Mauro Ravera; Sara Baracco; Claudio Cassino; Piero Zanello; Domenico Osella;
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1. Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl_4(DMSO)(Im)], NAMI-A [J] . Mauro Ravera, Sara Baracco, Claudio Cassino, Dalton transactions: An international journal of inorganic chemistry . 2004,第15期

机译：评价抗转移钌（III）配合物[ImH] [RuCl_4（DMSO）（Im）]，NAMI-A的氧化还原行为
2. Electrochemical studies of a series of antimetastatic mono- and di-ruthenium complexes [Na][trans-(RuCl4)-Cl-III(DMSO)(L)] and [Na](2)[{trans-(RuCl4)-Cl-III(DMSO)}(2)(mu-L)] (L = N-donor heterocyclic bridging ligand) [J] . Ravera M, Gabano E, Baracco S, Inorganica Chimica Acta . 2008,第9a10期

机译：一系列抗静电单钌和二钌配合物[Na] [反式-（RuCl4）-Cl-III（DMSO）（L）]和[Na]（2）[{反式-（RuCl4）-Cl -III（DMSO）}（2）（mu-L）]（L = N供体杂环桥联配体）
3. A theoretical study on the hydrolysis process of the antimetastatic ruthenium(III) complex NAMI-A [J] . Chen JC, Chen LM, Liao SY, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2007,第27期

机译：抗静电钌（III）配合物NAMI-A水解过程的理论研究
4. Redox Behaviour of the Pu(IV)/Pu(III) Couple in Nitric Acid – Pu(IV)-Nitrato Complexes Speciation [C] . X. Crozes, P. Moisy, G. Cote Plutonium futures-the science 2010 . 2010

机译：硝酸（Pu（IV）-Nitrato配合物）中Pu（IV）/ Pu（III）对的氧化还原行为
5. Microwave synthesis and thermal analysis of ruthenium-DMSO complexes. [D] . Chiu, Shengkuei. 2009

机译：钌-DMSO配合物的微波合成和热分析。
6. Novel Unsymmetrical Ru(III) and Mixed-valence Ru(III)/Ru(II)Dinuclear Compounds Related to the Antimetastatic Ru(III) Drug NAMI-A [O] . B. Serli, E. Iengo, T. Gianferrara, 2001

机译：新型不对称Ru（III）和混合价Ru（III）/ Ru（II）与抗转移Ru（III）药物NAMI-A相关的双核化合物
7. Structure-Activity Relationships for NAMI-A Type Complexes (HL)trans-RuCl4L(S-dmso)ruthenate(III) (L = Imidazole, Indazole, 1, 2, 4-Triazole, 4-Amino-1, 2, 4-triazole, and 1-Methyl-1, 2, 4-triazole)-: Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity [O] . -1

机译：Nami-A型配合物的结构 - 活性关系（HL）反式ruCl41（S-DMSO）钌（III）（L =咪唑，吲唑，1,2,4-三唑，4-氨基-1,2， 4-三唑和1-甲基-1,2,4-三唑） - ：水溶，氧化还原性质，蛋白质结合和抗增殖活性
8. Electrochemical Parameterization of Metal Complex Redox Potentials, Using the Ruthenium (III)/Ruthenium(II) Couple to Generate a Ligand Electrochemical Series. [R] . Lever, A. B. 1989

机译：金属配合物氧化还原电位的电化学参数化，使用钌（III）/钌（II）偶联产生配体电化学系列。

Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl_4(DMSO)(Im)], NAMI-A

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