The possible role of Gly residues in the prion octarepeat region in the coordination of Cu~(2+)ions

Marek Luczkowski; Henryk Koztowski; Anna Legowska; Krzysztof Rolka; MaurizioReraelli

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The possible role of Gly residues in the prion octarepeat region in the coordination of Cu~(2+)ions

机译：ly病毒八面体区域Gly残基在Cu〜（2+）离子配位中的可能作用

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Spectroscopic and potentiometric data have shown that insertion of tripeptides other than the Gly,peptide fragment,Ala_3 or Lys_3,into the prion octarepeat region destabilizes the biologically relevant Cu~(2+)complex with the metal ion bound equatorially through the {N_(imid),2N~-}.donor set.The other likely role of the high glycine content could be enforcement of the high flexibility of the N-terminal prion region resulting in the unstructured protein organization.However,the insertion of bulkier amino acid residues does not change the basic coordination mode at physiological pH which involves imidazole nitrogen and two amide nitrogen donors from the third and fourth residues.

机译：光谱和电位数据表明，将除Gly，肽片段，Ala_3或Lys_3以外的三肽插入病毒八面体区域，使具有生物学相关性的Cu〜（2+）络合物与通过{N_（imid ），2N〜-}。供体集合。高甘氨酸含量的另一个可能的作用可能是强制执行N末端region病毒区域的高柔韧性导致蛋白质的非结构化组织。但是，插入较大的氨基酸残基确实可以在生理pH下不改变基本配位模式，所述生理pH涉及咪唑氮和来自第三和第四残基的两个酰胺氮供体。

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《Dalton transactions: An international journal of inorganic chemistry》 |2003年第4期|共6页
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Marek Luczkowski; Henryk Koztowski; Anna Legowska; Krzysztof Rolka; MaurizioReraelli;
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1. The possible role of Gly residues in the prion octarepeat region in the coordination of Cu~(2+)ions [J] . Marek Luczkowski, Henryk Koztowski, Anna Legowska, Dalton transactions: An international journal of inorganic chemistry . 2003,第4期

机译：ly病毒八面体区域Gly残基在Cu〜（2+）离子配位中的可能作用
2. Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein. [J] . Remelli M, Valensin D, Toso L, Metallomics. integrated biometal science . 2012,第8期

机译：热力学和光谱学研究Met残基在Cu（II）与人类病毒蛋白非八面体位点结合中的作用。
3. Computational studies of Cu(II)[peptide] binding motifs: Cu[HGGG] and Cu[HG] as models for Cu(II) binding to the prion protein octarepeat region [J] . M. Jake Pushie, Arvi Rauk Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2003,第1a2期

机译：Cu（II）[肽]结合基序的计算研究：Cu [HGGG]和Cu [HG]作为Cu（II）结合the病毒蛋白八面体区域的模型
4. Replacement of Residue H95 with Charged Amino Acids in the Prion Protein Decreases Prion Conversion Propensity [C] . Thanh Hoa Tran, Giuseppe Legname International Conference on the Development of Biomedical Engineering in Vietnam . 2020

机译：在朊病毒蛋白中用带电氨基酸替换残留物H95降低了朊病毒转化率
5. Adsorption and reaction of Pb(2+) and Cu(2+) on pristine and modified oxides in aqueous suspension. [D] . Weesner, Forrest James. 1997

机译：Pb（2+）和Cu（2+）在水悬浮液中的原始氧化物和改性氧化物上的吸附和反应。
6. Modeling by Assembly and Molecular Dynamics Simulations of the Low Cu2+ Occupancy Form of the Mammalian Prion Protein Octarepeat Region: Gaining Insight into Cu2+-Mediated β-Cleavage [O] . M. Jake Pushie, Hans J. Vogel 2008

机译：通过组装和分子动力学模拟的哺乳动物on病毒蛋白八面体区域的低Cu2 +占用形式：深入了解Cu2 +介导的β切割。
7. Modeling by Assembly and Molecular Dynamics Simulations of the Low Cu2+ Occupancy Form of the Mammalian Prion Protein Octarepeat Region: Gaining Insight into Cu2+-Mediated β-Cleavage [O] . Pushie, M. Jake, Vogel, Hans J. 2008

机译：通过组装和分子动力学模拟的哺乳动物Pri病毒蛋白八面体区域的低Cu2 +占用形式：深入了解Cu2 +介导的β切割。

The possible role of Gly residues in the prion octarepeat region in the coordination of Cu~(2+)ions

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