Oxidative DNA damage induced by autoxidation of microquantities of S(IV)in the presence of Ni(II)-Gly-Gly-His

Maria V.Alipazaga; Ruben G.M.Moreno; Edlaine Linares; Marisa H.G.Medeiros; Nina Coichev

首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Oxidative DNA damage induced by autoxidation of microquantities of S(IV)in the presence of Ni(II)-Gly-Gly-His

【24h】

Oxidative DNA damage induced by autoxidation of microquantities of S(IV)in the presence of Ni(II)-Gly-Gly-His

机译：Ni（II）-Gly-Gly-His存在下S（IV）微量自氧化引起的DNA氧化损伤

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Ni~(II)GGH(GGH=glycylglycylhistidine)reacts rapidly with S(IV),in air-saturated solution,to produce Ni~(III)GGH.A mechanism is proposed where initial Ni~(III)oxidizes SO_3~(2-)to SO_3~(centre dot-),which reacts with dissolved oxygen to produce SO_5~(centre dot-),initiating radical chain reactions.DNA strand breaks and 8-oxo-7,8-dihydro-2'-deoxyguanosine formation were observed in air-saturated solutions containing micromolar concentrations of Ni(II)and S(IV).The extent of DNA damage showed dependence on the ratio of the Ni~(II)GGH:S(IV)concentrations and the ionic strength.

机译：Ni〜（II）GGH（GGH = glycylglycylhistidine）与S（IV）在空气饱和溶液中快速反应生成Ni〜（III）GGH。提出了初始Ni〜（III）氧化SO_3〜（2）的机理-）至SO_3〜（中心点-），与溶解氧反应生成SO_5〜（中心点-），引发自由基链反应.DNA链断裂并形成8-oxo-7,8-dihydro-2'-deoxyguanosine在含有微摩尔浓度的Ni（II）和S（IV）的空气饱和溶液中观察到DNA损伤的程度显示出与Ni〜（II）GGH：S（IV）浓度之比和离子强度有关。

著录项

来源
《Dalton transactions: An international journal of inorganic chemistry》 |2005年第23期|共7页
作者
Maria V.Alipazaga; Ruben G.M.Moreno; Edlaine Linares; Marisa H.G.Medeiros; Nina Coichev;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类无机化学;
关键词

相似文献

外文文献
中文文献
专利

1. Oxidative DNA damage induced by autoxidation of microquantities of S(IV)in the presence of Ni(II)-Gly-Gly-His [J] . Maria V.Alipazaga, Ruben G.M.Moreno, Edlaine Linares, Dalton transactions: An international journal of inorganic chemistry . 2005,第23期

机译：Ni（II）-Gly-Gly-His存在下S（IV）微量自氧化引起的DNA氧化损伤
2. DNA damage induced by the autoxidation of S(IV) in the presence of transition metal ions [J] . Alipázaga María V., Coichev Nina, Medeiros Marisa H. G., Quimica nova . 2006,第5期

机译：在过渡金属离子存在下S（IV）自氧化引起的DNA损伤
3. DNA damage and 2'-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion [J] . Moreno RG, Alipazaga MV, Gomes OF, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2007,第5期

机译：铜（II）四甘氨酸配合物催化的S（IV）自氧化诱导的DNA损伤和2'-脱氧鸟苷氧化：第二种金属离子的协同作用
4. Effects of Tea Polyphenols on Ni_2O_3-Induced Lipid Peroxidation in Rat Alveolar Macrophage and DNA Damage of HLF Cells [C] . ZHANG Jun, ZHANG Jing, SHI Hongjun, Annual Conference for Young Scientists of China Association for Science and Technology; 20041102-05; Shanghai(CN) . 2004

机译：茶多酚对Ni_2O_3-诱导的大鼠肺泡巨噬细胞脂质过氧化和HLF细胞DNA损伤的影响
5. The cell cycle phase specificity of DNA damage induced by radiation, peroxide and chemotherapeutic drugs targeting topoisomerase II, and CD4 and CD8 receptor expression on apoptotic human lymphocytes. [D] . Potter, Alan J. 2003

机译：靶向拓扑异构酶II的放射线，过氧化物和化学治疗药物诱导的DNA损伤的细胞周期相位特异性，以及凋亡的人类淋巴细胞上CD4和CD8受体的表达。
6. A mutant endonuclease IV of Escherichia coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate. [O] . T Izumi, K Ishizaki, M Ikenaga, 1992

机译：大肠杆菌的突变型核酸内切酶IV丧失了修复过氧化氢诱导的致死性DNA损伤的能力但没有修复甲磺酸甲酯引起的致死性DNA损伤的能力。
7. Lesões em DNA induzidas pela autoxidação de S(IV) na presença de íons metálicos de transição DNA damage induced by the autoxidation of S(IV) in the presence of transition metal ions [O] . Ruben G. M. Moreno, María V. Alipázaga, Marisa H. G. Medeiros, 2006

机译：在过渡金属离子存在下由S（IV）自氧化引起的DNA损伤在过渡金属离子存在下由S（IV）自氧化引起的DNA损伤

Oxidative DNA damage induced by autoxidation of microquantities of S(IV)in the presence of Ni(II)-Gly-Gly-His

摘要

著录项

相似文献

相关主题

期刊订阅