Synthesis, characterization and electrochemical studies of mixed ligand complexes of ruthenium(II) with DNA

Vaidyanathan VG; Nair BU

首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Synthesis, characterization and electrochemical studies of mixed ligand complexes of ruthenium(II) with DNA

【24h】

Synthesis, characterization and electrochemical studies of mixed ligand complexes of ruthenium(II) with DNA

机译：钌（II）与DNA混合配体配合物的合成，表征和电化学研究

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two mixed ligand complexes of ruthenium(II) [Ru(bzimpy)(bpy)(OH2)](2+) (1) and [Ru(bzimpy)(phen)(OH2)](2+) (2) have been synthesized and characterized by FAB mass, H-1 NMR, cyclic voltammetry and spectroelectrochemical measurements. Controlled potential electrolysis of these complexes results in the conversion of ruthenium(II) to ruthenium(III) at 0.6 V and ruthenium(III) to ruthenium(IV) at 0.8 V vs. SCE. The binding constant of these complexes with DNA has been determined electrochemically and found to be (3.58 +/- 0.25) x 10(4) and (2.87 +/- 0.2) x 10(4) M-1. Viscosity measurements suggest that these complexes bind with DNA through intercalation. Such intercalative binding to DNA has been found to induce chirality to the two complexes. Electrochemically generated ruthenium(IV) species of these complexes have been found to bring about oxidative cleavage in DNA.

机译：钌（II）[Ru（bzimpy）（bpy）（OH2）]（2+）（1）和[Ru（bzimpy）（phen）（OH2）]（2+）（2）的两种混合配体配合物合成并通过FAB质量，H-1 NMR，循环伏安法和光谱电化学测量进行表征。与SCE相比，这些配合物的受控电势电解可在0.6 V下将钌（II）转化为钌（III），在0.8 V下将钌（III）转化为钌（IV）。这些复合物与DNA的结合常数已通过电化学方法确定，发现为（3.58 +/- 0.25）x 10（4）和（2.87 +/- 0.2）x 10（4）M-1。粘度测量表明这些复合物通过嵌入与DNA结合。已经发现这种与DNA的插入结合诱导了两种复合物的手性。已经发现这些配合物的电化学生成的钌（IV）物种可导致DNA的氧化裂解。

著录项

来源
《Dalton transactions: An international journal of inorganic chemistry》 |2005年第17期|共7页
作者
Vaidyanathan VG; Nair BU;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类无机化学;
关键词
CRYSTAL-STRUCTURE; SPECTROELECTROCHEMICAL PROPERTIES; ANCILLARY LIGANDS; BINDING; OXORUTHENIUM(IV); COBALT(III); CLEAVAGE; REDOX;

机译：晶体结构;分光电化学性质;辅助液体;键合;氧杂OX（IV）;钴（III）;裂解;氧化还原;

相似文献

外文文献
中文文献
专利

1. Synthesis, characterization and electrochemical studies of mixed ligand complexes of ruthenium(II) with DNA [J] . Vaidyanathan VG, Nair BU Dalton transactions: An international journal of inorganic chemistry . 2005,第17期

机译：钌（II）与DNA混合配体配合物的合成，表征和电化学研究
2. Synthesis, characterization and DNA-binding studies of ruthenium(II)mixed-ligand complexes containing dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline [J] . Bin Peng, Xiang Chen, Ke-Jie Du, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2009,第4期

机译：含吡啶并[1,2,5]恶二唑并[3,4-b]喹喔啉的钌（II）混合配体配合物的合成，表征和DNA结合研究
3. Synthesis, characterization and DNA binding studies of two mixed ligand complexes of ruthenium(II) [J] . Lawrence D, Vaidyanathan VG, Nair BU Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2006,第7期

机译：两种钌（II）混合配体配合物的合成，表征和DNA结合研究
4. Synthesis and Characterization of Mono and Mixed Ligand, Ni(II), Pd(II) and Pt(II) Complexes of S-5-Phenyl -1, 3, 4-Oxadiazole-2-yl Benzothioate with some Tertiary Diphosphines Ligands [C] . R. A. Saleh, H. A. Mohammad, T. I. Gerber, International Conference and Workshops on Basic and Applied Sciences . 2017

机译：S-5-苯基-1,3,4-二氧化氮-2-基苯并噻吩二叔二膦配体的S-5-苯基-1,3,4-二氮唑-2-基苯甲酸酯的单氧和混合配体，Ni（II），Pd（II）和Pt（II）配合物的合成及表征
5. IRON AND RUTHENIUM COMPLEXES POSSESSING UNUSUAL ELECTRONIC PROPERTIES. PART I: SYNTHESIS AND SPIN STATE STUDIES OF GAMMA-SUBSTITUTED TRIS(BETA-DIKETONATO)IRON(III) COMPLEXES AND THEIR BETA-KETOIMINE ANALOGUES DERIVED FROM TRIETHYLENETETRAMINE. PART II: A DIRECT MEASUREMENT OF DYNAMIC SPIN INTERCONVERSION RATES IN THE SPIN EQUILIBRIUM PROTEIN FERRIC MYOGLOBIN HYDROXIDE. PART III: SYNTHESIS, PHOTOEMISSION, AND ELECTROCHEMICAL STUDIES OF. [D] . DOSE, ERIC VON. 1978

机译：铁和钌络合物具有异常的电子特性。第一部分：γ-取代的三（三乙酮）铁（III）配合物及其三乙胺丁胺类似物的β-酮亚胺类似物的合成和自旋态研究。第二部分：纺丝平衡蛋白三水合肌红蛋白中动态纺丝互变速率的直接测量。第三部分：的合成，光生化和电化学研究。
6. Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents [O] . Floyd A. Beckford, Jeffrey Thessing, Michael Shaloski Jr., -1

机译：钌（II）混合配体二嘧啶 - 哌啶硫代噻唑哌啶醇的合成与表征：生物物理研究和生物学评价作为抗癌和抗菌剂
7. Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding [O] . Megha S Deshpande, Avinash S Kumbhar 2005

机译：钌（II）的混合配体络合物（II）掺入DiaZo配体：合成，表征和DNA结合

Synthesis, characterization and electrochemical studies of mixed ligand complexes of ruthenium(II) with DNA

摘要

著录项

相似文献

相关主题

期刊订阅