Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H(4)dota and comparative kinetic study of yttrium(III) complexes

Forsterova M; Svobodova I; Lubal P; Taborsky P; Kotek J; Hermann P; Lukes I

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Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H(4)dota and comparative kinetic study of yttrium(III) complexes

机译：镧（III）与H（4）dota双功能单次膦酸类似物的配合物的热力学研究和钇（III）配合物的比较动力学研究

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New bifunctional H(4)dota-like ligands with three acetic acid and one phosphinic acid pendant arms and propionate (H(5)do3ap(PrA)) or 4-aminobenzyl (H(4)do3ap(ABn)) reactive groups bound to the phosphorus atom were investigated. Potentiometric studies showed that the ligands have a similar basicity to the parent H(4)dota and the stability constants of their complexes with sodium(I) and selected lanthanide(III) ions are also similar. Formation and acid-assisted decomplexation kinetics of yttrium(III) complexes with a series of H(4)dota- like ligands (H(4)dota and its phosphinic/phosphonic acid analogues) were studied and the reactions are sensitive to a slight modi. cation of the ligand structure. The (2-carboxyethyl) phosphinic acid derivative H(5)do3apPrA and the phosphonic acid ligand H(5)do3ap form complexes faster than H(4)dota. The most kinetically inert complex is that with H(4)do3apABn. Rates of complexation and decomplexation can depend on the ability to transfer proton(s) outside/inside the complex cavity and, therefore, on the hydrophobicity of the ligands. The results demonstrate that the new bifunctional ligands are suitable for labelling biomolecules with yttrium(III) radioisotopes for utilization in nuclear medicine.

机译：具有三个乙酸和一个次膦酸侧链和丙酸酯（H（5）do3ap（PrA））或4-氨基苄基（H（4）do3ap（ABn））反应性基团的新双功能H（4）dota状配体研究了磷原子。电位研究表明，配体与母体H（4）dota具有相似的碱性，并且它们与钠（I）和选定的镧系元素（III）离子形成的配合物的稳定性常数也相似。钇（III）配合物与一系列H（4）dota-like配体（H（4）dota及其次膦酸/膦酸类似物）的形成和酸辅助分解动力学进行了研究，反应对轻微的修饰敏感。配体结构的阳离子。（2-羧乙基）次膦酸衍生物H（5）do3apPrA和膦酸配体H（5）do3ap形成络合物比H（4）dota更快。最具有动力学惰性的复合物是H（4）do3apABn。络合和解络的速率可以取决于质子在复合腔内外转移的能力，因此取决于配体的疏水性。结果表明，新的双功能配体适用于钇（III）放射性同位素标记生物分子，用于核医学。

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《Dalton transactions: An international journal of inorganic chemistry》 |2007年第5期|共15页
作者
Forsterova M; Svobodova I; Lubal P; Taborsky P; Kotek J; Hermann P; Lukes I;
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正文语种 eng
中图分类无机化学;
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MACROCYCLIC POLYAMINO CARBOXYLATES; NUCLEAR MAGNETIC-RESONANCE; WATER EXCHANGE-RATE; CRYSTAL-STRUCTURES; ARSENAZO-III; DOTA ANALOG; METAL-IONS; 1; 4; 8; 11-TETRAAZACYCLOTETRADECANE-1; 8-BIS(METHYLPHOSPHONIC ACID); 1; 4; 7; 10-TETRAAZACYCLODODECANE-N; N'; N''; N'''-TETRAACETIC ACID; STRUCTURAL-CHARACTERIZATION;

机译：大环多羧酸盐;核磁共振;水交换率;晶体结构;AR-III;DOTA模拟;金属离子;1;4;8;11-四氮杂环戊烷-1;8-双（乙）甲酰基;4;7;10-四氮杂环十二烷-N;N';N'';N'''-四乙酸;结构表征;

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1. Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H(4)dota and comparative kinetic study of yttrium(III) complexes [J] . Forsterova M, Svobodova I, Lubal P, Dalton transactions: An international journal of inorganic chemistry . 2007,第5期

机译：镧（III）与H（4）dota双功能单次膦酸类似物的配合物的热力学研究和钇（III）配合物的比较动力学研究
2. THERMODYNAMIC AND KINETIC STUDIES OF LANTHANIDE(III) COMPLEXES WITH H_5do3ap (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC-10-(METHYLPHOSPHONIC ACID)),A MONO-PHOSPHONATE ANALOGUE OF H_4dota [J] . Petr TABORSKY, Premysl LUBAL, Josef HAVEL, Collection of Czechoslovak Chemical Communications . 2005,第11期

机译：H_5do3ap（1,4,7,10-四氮杂环十二烷-1,4,7-三乙酰-10-（甲基膦酸））的镧系元素配合物的热力学和动力学研究，H_4dota的单膦酸酯类似物
3. Equilibrium and kinetic studies on the formation of the lanthanide(III) complexes, [Ce(dota)](-) and [Yb(dota)](-) (H(4)dota=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) [J] . Burai L., Kiraly R., Szilagyi E., Journal of the Chemical Society, Dalton Transactions. Inorganic Chemistry . 1998,第2期

机译：镧系元素（III）配合物[Ce（dota）]（-）和[Yb（dota）]（-）（H（4）dota = 1,4,7,10-四氮杂十二烷的形成）的平衡和动力学研究-1,4,7,10-四乙酸）
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Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H(4)dota and comparative kinetic study of yttrium(III) complexes

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