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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Metal based drugs: from serendipity to design
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Metal based drugs: from serendipity to design

机译：金属基药物：从偶然性到设计

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The platinum anticancer drug cisplatin has made a major contribution to the treatment of testicular and ovarian cancer. This chance discovery has been the stimulus for research into other metal-based drugs. Inorganic chemistry offers many opportunities for medicinal chemistry, and the discovery of metal-based drugs has moved on from chance discovery to rational drug design. There are however, many challenges associated with the drug discovery and development process. The aim of this review is to provide case histories exemplifying the role of rational drug design in modern inorganic medicinal chemistry in the context of these challenges. The evolution of platinum drugs from cisplatin to third generation drugs is described. The molecular target for the platinum agents is DNA. Alternative molecular targets such as thiol-containing proteins and redox processes are proposed. The example of a simple, safe, efficacious metal-based drug, Fosrenol (TM), is reviewed.
机译：铂类抗癌药顺铂为睾丸和卵巢癌的治疗做出了重要贡献。这个机会发现一直是其他金属基药物研究的动力。无机化学为药物化学提供了许多机会，金属基药物的发现已从偶然发现转向合理的药物设计。但是，与药物发现和开发过程相关的挑战很多。这篇综述的目的是提供案例历史，以说明在这些挑战的背景下合理的药物设计在现代无机药物化学中的作用。描述了铂药物从顺铂到第三代药物的演变。铂试剂的分子靶标是DNA。提出了替代的分子靶标，例如含硫醇的蛋白质和氧化还原过程。本文回顾了一种简单，安全，有效的基于金属的药物Fosrenol（TM）的实例。

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