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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >YVO _4:Eu ~(3+) functionalized porous silica submicrospheres as delivery carriers of doxorubicin
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YVO _4:Eu ~(3+) functionalized porous silica submicrospheres as delivery carriers of doxorubicin

机译：YVO _4：Eu〜（3+）功能化多孔二氧化硅亚微球作为阿霉素的递送载体

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Porous silica microspheres were fabricated by a facile surface-protected etching strategy. Polyvinylpyrrolidone (PVP) was used as a protecting polymer absorbed on the surface of silica microspheres and NaOH was employed as an etching agent. Owing to the protective action of PVP and inhomogeneous etching, mesopores were created in the silica microspheres. Then, based on the Pechini-type sol-gel and impregnating process, YVO _4:Eu ~(3+) nanocrystals were integrated into the channels to form highly luminescent YVO _4:Eu ~(3+)@SiO _2 composite microspheres. The biocompatibility tests on L929 fibroblast cells using MTT assay reveal low cytotoxicity of the system. Owing to the large interior space and electrostatic interaction, the porous microspheres show a relatively high loading capacity (438 mg DOX/YVO _4:Eu ~(3+)@SiO _2 g) and encapsulation efficiency (87.6%) for the anti-cancer drug doxorubicin hydrochloride (DOX). The drug release behavior and cytotoxic effect against human cervical carcinoma cells (HeLa cells) of the DOX-loaded YVO _4:Eu ~(3+)@SiO _2 carriers were investigated in vitro. It was found that the carriers present a highly pH-dependent drug release behavior due to electrostatic interaction between the silica surface and DOX molecules. The drug release rate became greater at low pH owing to the increased electrostatic repulsion. The DOX-loaded carriers demonstrate a similar or even greater anti-cancer activity with respect to the free DOX against HeLa cells. Furthermore, the PL intensity of the microspheres shows correlation with the cumulative release of DOX. These results suggest that the composite can potentially act as a multifunctional drug carrier system with luminescent tagging and pH-controlled release properties.
机译：多孔二氧化硅微球是通过简便的表面保护刻蚀策略制成的。聚乙烯吡咯烷酮（PVP）被用作吸附在二氧化硅微球表面的保护聚合物，而NaOH被用作蚀刻剂。由于PVP的保护作用和不均匀的蚀刻，在二氧化硅微球中产生了中孔。然后，基于Pechini型溶胶-凝胶和浸渍过程，将YVO _4：Eu〜（3+）纳米晶体整合到通道中，以形成高发光度的YVO _4：Eu〜（3 +）@ SiO _2复合微球。使用MTT分析法对L929成纤维细胞进行的生物相容性测试表明，该系统的细胞毒性较低。由于较大的内部空间和静电相互作用，多孔微球显示出较高的负载能力（438 mg DOX / YVO _4：Eu〜（3 +）@ SiO _2 g）和包封效率（87.6％）药物阿霉素盐酸盐（DOX）。体外研究了载有DOX的YVO _4：Eu〜（3 +）@ SiO _2载体对人宫颈癌细胞（HeLa细胞）的释药行为和细胞毒作用。发现由于二氧化硅表面和DOX分子之间的静电相互作用，载体表现出高度pH依赖性药物释放行为。由于静电排斥力的增加，在低pH下药物释放速率变得更大。相对于针对HeLa细胞的游离DOX，负载DOX的载体表现出相似甚至更大的抗癌活性。此外，微球的PL强度显示与DOX的累积释放相关。这些结果表明该复合材料可以潜在地充当具有发光标签和pH控制释放特性的多功能药物载体系统。

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