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首页> 外文期刊>Dermatologic surgery >Clonidine premedication decreases propofol consumption during bispectral index (BIS) monitored propofol-ketamine technique for office-based surgery.
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Clonidine premedication decreases propofol consumption during bispectral index (BIS) monitored propofol-ketamine technique for office-based surgery.

机译：可乐定的处方药可减少双光谱指数（BIS）监测的异丙酚-氯胺酮技术在办公室手术中的异丙酚消耗量。

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摘要

BACKGROUND: Propofol-ketamine anesthesia is a room air, spontaneous ventilation (RASV), dissociative intravenous (IV) sedation technique reported to have a near-zero postoperative nausea and vomiting (PONV) rate. Clonidine premedication has been reported to control blood pressure intra- and postoperatively, as well as to reduce the requirements for hypnotic agents. The bispectral index (BIS) monitor is a reproducible, objective, observer independent, quantitative measurement of the hypnotic state. OBJECTIVE: This study was designed to compare the propofol consumption rate during BIS monitored propofol-ketamine anesthesia for office-based, elective female facial rhytidectomy in patients with and without clonidine premedication. METHODS: Six patients receiving clonidine (200 microg oral premedication administered 30-60 minutes prior to induction of anesthesia were compared with a recent, historical control group of six patients who received no premedication. A BIS of 60-70 was chosen as the standard of comparison for light hypnotic state. A dilute propofol solution was used to gradually titrate anesthesia to a BIS of 60-70 prior to the administration of ketamine. RESULTS: A statistically significant reduction in propofol consumption was observed in the clonidine premedicated female elective rhytidectomy patients compared with those not receiving the clonidine. Other than modestly increased requirements for IV fluids, there were no adverse effects observed with clonidine premedication.
机译：背景：丙泊酚氯胺酮麻醉是一种室内空气，自发通气（RASV），离解性静脉内（IV）镇静技术，据报道术后恶心和呕吐（PONV）率接近于零。据报道，可乐定的处方药可以在术中和术后控制血压，并减少对催眠药的需求。双光谱指数（BIS）监视器是可重复的，客观的，与观察者无关的，对催眠状态的定量测量。目的：本研究旨在比较在采用BIS监测的异丙酚-氯胺酮麻醉下，有无可乐定患者的办公室择期女性面部除皱术中的异丙酚消耗率。方法：将6名接受可乐定（200微克口服前用药，在麻醉诱导前30-60分钟给药）的患者与最近的历史对照组（6名未用药的患者）进行比较，以60-70的BIS作为标准。比较：在使用氯胺酮之前，使用稀释的异丙酚溶液逐步将麻醉滴定至BIS 60-70，结果在可乐定治疗的女性选择性除皱术患者中，异丙酚的摄入量有统计学意义的降低。除了适度增加静脉输液的需求量外，可乐定的处方药未观察到不良反应。

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