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首页> 外文期刊>Dermatologic surgery >Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma
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Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma

机译：Mentis恶性黑色素瘤原位癌和Lentigo恶性黑色素瘤莫氏手术中MITF和Melan-A免疫组织化学的比较

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BACKGROUNDMohs micrographic surgery (MMS) with frozen section immunohistochemistry is a treatment option for malignant melanoma in situ (MMIS) and lentigo maligna melanoma (LMM). Melan-A is a cytoplasmic melanocyte immunostain useful on frozen sections but may lack specificity. Microphthalmia transcription factor (MITF) is a more specific nuclear melanocyte immunostain less frequently used in MMS.OBJECTIVETo quantify melanocyte density in chronic sun-damaged skin (CSDS), negative margin, and tumor from patients undergoing MMS for MMIS and LMM using MITF and melan-A.METHODSSixteen patients with MMIS or LMM had frozen sections from CSDS, negative margin, and 12 tumor samples, stained with MITF and melan-A. Melanocyte counts were performed.RESULTSChronic sun-damaged skin mean melanocyte count (MMC) for MITF and melan-A was 9.8 and 13.7, respectively, (p < .001). Negative margin MMC for MITF and melan-A was 8.84 and 14.06, respectively, (p < .001). Tumor MMC for MITF and melan-A was 63.5 and 62.4, respectively.CONCLUSIONAlthough both MITF and melan-A facilitate the identification of tumor during MMS for MMIS and LMM, the apparent melanocyte density on tumor-free CSDS appears higher with melan-A than MITF. Microphthalmia transcription factor provides a crisp outline of melanocyte nuclei and is a useful alternative stain to melan-A for MMS of melanoma.
机译：背景技术采用冰冻切片免疫组织化学的莫氏显微外科手术（MMS）是原位恶性黑色素瘤（MMIS）和恶性扁桃恶性黑色素瘤（LMM）的治疗选择。 Melan-A是可用于冰冻切片的细胞质黑素细胞免疫染色剂，但可能缺乏特异性。小眼症转录因子（MITF）是一种较特异的MMS较不特异的核黑色素细胞免疫印迹。 -A。方法16例MMIS或LMM患者的冰冻切片来自CSDS，阴性切缘和12个肿瘤样品，均用MITF和melan-A染色。结果：MITF和melan-A的慢性太阳损伤皮肤平均黑素细胞计数（MMC）分别为9.8和13.7，（p <.001）。 MITF和melan-A的负边缘MMC分别为8.84和14.06，（p <.001）。结论MITF和melan-A的肿瘤MMC分别为63.5和62.4。 MITF。小眼症转录因子可提供黑色素细胞核的清晰轮廓，是黑色素瘤MMS有用的黑色素A替代染色剂。

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