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首页> 外文期刊>Dermatologic surgery >Cutaneous carcinosarcoma: report of a case with myofibroblastic sarcomatous component.
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Cutaneous carcinosarcoma: report of a case with myofibroblastic sarcomatous component.

机译:皮肤癌肉瘤:肌纤维母细胞肉瘤成分的报告。

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摘要

Carcinosarcoma is a rare biphasic tumor combining malignant epithelial and mesenchymal elements, which may occur in several anatomical areas, including the skin, where a total of 42 cases have been reported up to 2005. It occurs primarily in elderly patients on sun-damaged skin, and the lesion either develops rapidly or has been present for years and increases suddenly in size. One case has been described in association with nevoid basal cell carcinoma syndrome. Histologically, the epithelial component can be of epidermal type (basal or squamous cell carcinoma; 57% of reported cases) or adnexal type (spiradenocarcinoma, porocarcinoma, proliferating tricholemmal cystic carcinoma, or matrical carcinoma; 43% of reported cases), while the mesenchymal component can show osseous, cartilagenous, or more rarely, skeletal or smooth muscle differentiation; no differentiation in nerve tissue has been as yet shown.Here, we present a case of cutaneous carcinosarcoma in which the mesenchymal component showed myofibroblastic differentiation at the ultrastructural level. So far, to our knowledge, this type of mesenchymal component has not been described in the literature.
机译:癌肉瘤是一种罕见的双相型肿瘤,由恶性上皮和间质组成,可能发生在包括皮肤在内的多个解剖区域,截止到2005年,总共报告了42例。它主要发生在遭受阳光照射的皮肤上的老年患者中,病变要么发展迅速,要么已经存在多年,并且大小突然增加。已经描述了与空洞性基底细胞癌综合征相关的一例。从组织学上讲,上皮成分可以是表皮型(基底或鳞状细胞癌;报告病例的57%)或附件型(螺旋腺癌,多孔癌,增生性三孔性胆囊癌或母性癌;报告病例的43%),而间充质成分可以显示骨骼,平滑肌分化为骨质,软骨质,或更罕见。尚未显示神经组织的分化。在此,我们介绍了一例皮肤癌肉瘤,其中间质成分在超微结构水平显示了肌成纤维细胞分化。到目前为止,据我们所知,这种间充质成分尚未在文献中描述。

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