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首页> 外文期刊>Dermatologic surgery >Keloids and hypertrophic scars: are they two different sides of the same coin?
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Keloids and hypertrophic scars: are they two different sides of the same coin?

机译：瘢痕loid和肥厚性疤痕：它们是同一枚硬币的两个不同侧面吗？

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摘要

Keloids and hypertrophic scars are different forms of excessive dermal fibrosis thought to be caused by regulation of cellularity increase and decrease during the wound-healing process in predisposed individuals. Differences between keloids and hypertrophic scars include distinct clinical features, histologic evidence, and cellular function in response to molecular events. Keloids and hypertrophic scars are the results of increased fibroblast density and extracellular matrix substances. Interactions between epidermal keratinocytes and dermal fibroblasts play an important role in regulating tissue homeostasis and processing scar formation. Keloids and hypertrophic scars are the two different stages of the same process that is based on separate clinical and histochemical entities. The aim of this review is to provide updated information regarding similarities and differences between keloids and hypertrophic scars as two different sides of the same coin. This article will also enable the dermatologist to better understand fundamental biology of the scarring.
机译：瘢痕loid和肥厚性瘢痕是不同形式的皮肤过度纤维化，被认为是由易患个体在伤口愈合过程中调节细胞增多和减少引起的。瘢痕loid和肥厚性瘢痕之间的差异包括独特的临床特征，组织学证据和对分子事件的反应的细胞功能。瘢痕loid和肥厚性瘢痕是成纤维细胞密度和细胞外基质物质增加的结果。表皮角质形成细胞和真皮成纤维细胞之间的相互作用在调节组织稳态和加工疤痕形成中起重要作用。瘢痕loid和肥厚性瘢痕是同一过程的两个不同阶段，基于不同的临床和组织化学实体。这篇综述的目的是提供有关瘢痕loid和肥厚性瘢痕（作为同一枚硬币的两个不同面）之间的相似性和差异的更新信息。本文还将使皮肤科医生更好地了解疤痕的基本生物学。

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