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首页> 外文期刊>Dermatologic surgery >Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers.
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Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers.

机译：新鲜成纤维细胞同种异体移植物治疗糖尿病足溃疡的功效和安全性。

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BACKGROUND AND OBJECTIVE: Various types of allogenic skin substitutes composed of cryopreserved keratinocytes, fibroblasts, or both have been used for treatments of diabetic foot ulcers, but the effects have generally not been dramatic because cryopreservation impairs cell activities. The purpose of the study was to evaluate the use of non-cryopreserved fresh human fibroblast allografts in treating diabetic foot ulcers. MATERIALS AND METHODS: Human dermal fibroblasts from healthy teenagers were cultured and applied over the foot ulcers of 37 patients with diabetes. Control treatment was performed in 18 patients. Eight weeks after treatment, the percentages of complete healing, mean healing times, and patient satisfaction were compared, with follow-up ranging from 6 to 40 months. RESULTS: Our study showed that 83.8% of the treated group and 50.0% of the control group experienced complete healing. The times required for complete healing were 30.9+/-10.1 and 47.2+/-7.8 days in the treated and control groups, respectively. Patient satisfaction with fresh fibroblast treatment was also superior to satisfaction with the conventional method (mean scores: 8.0+/-1.0 and 4.9+/-1.4, respectively). No adverse events related to the study treatment occurred. CONCLUSION: The use of fresh human fibroblast allografts was found to be a safe and effective treatment for diabetic foot ulcers. The authors have indicated no significant interest with commercial supporters.
机译：背景和目的：由冷冻保存的角质形成细胞，成纤维细胞或两者组成的各种同种异体皮肤替代品已被用于治疗糖尿病足溃疡，但由于冷冻保存会损害细胞活性，因此其作用通常并不显着。这项研究的目的是评估未冷冻保存的新鲜人成纤维细胞同种异体移植物在治疗糖尿病足溃疡中的用途。材料与方法：培养健康少年的人真皮成纤维细胞，并将其施用于37例糖尿病患者的足溃疡上。在18例患者中进行了对照治疗。治疗后八周，比较了完全治愈，平均治愈时间和患者满意度的百分比，随访时间为6至40个月。结果：我们的研究表明，治疗组的83.8％和对照组的50.0％经历了完全愈合。在治疗组和对照组中，完全愈合所需的时间分别为30.9 +/- 10.1天和47.2 +/- 7.8天。患者对新鲜成纤维细胞治疗的满意度也优于常规方法（平均评分分别为8.0 +/- 1.0和4.9 +/- 1.4）。没有发生与研究治疗有关的不良事件。结论：使用新鲜的人成纤维细胞同种异体移植物是治疗糖尿病足溃疡的安全有效方法。作者表示对商业支持者没有太大兴趣。

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