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首页> 外文期刊>Dermatologic surgery >Treatment of melasma in Asian skin using a fractional 1,550-nm laser: an open clinical study.
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Treatment of melasma in Asian skin using a fractional 1,550-nm laser: an open clinical study.

机译：使用部分1,550 nm激光治疗亚洲皮肤中的黄褐斑：一项开放的临床研究。

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BACKGROUND: Melasma is a common hyperpigmentation disorder that can cause refractory cosmetic disfigurement, especially in Asians. Fractional photothermolysis (FP) has been reported to be effective for the treatment of melasma, despite small study populations and short follow-up periods. OBJECTIVE: To evaluate the efficacy and safety of FP for the treatment of melasma in Asians. PATIENTS AND METHODS: Twenty-five patients with melasma received four monthly FP sessions and were followed up to 24 weeks after treatment completion. Efficacy was evaluated using objective and subjective ratings, Melasma Area and Severity Index (MASI), melanin index tracking, and skin elasticity measurements. RESULTS: Investigators observed clinical improvements in 60% and patients in 44% at 4 weeks after treatment, but the figures decreased to 52% and 35%, respectively, at 24 weeks after treatment. Mean MASI scores decreased significantly from 7.6 to 6.2. Mean melanin index decreased significantly after the first two sessions, but it relapsed slightly in subsequent follow-ups. The treatment did not alter skin elasticity. Hyperpigmentation was observed in three of 23 subjects (13%). CONCLUSION: Treatment of melasma with FP led to some clinical improvements, but it was not as efficacious as previously reported at 6-month follow-up. We recommend judicious use of FP for the treatment of melasma in Asian skin because of its limited efficacy.
机译：背景：黄褐斑是一种常见的色素沉着过度症，可导致难治性的容貌毁损，尤其是在亚洲人中。尽管研究人群少且随访时间短，但已有报道称部分光热解法（FP）可有效治疗黄褐斑。目的：评价FP治疗亚洲人黄褐斑的疗效和安全性。患者与方法：25名黄褐斑患者每月接受四个FP疗程，并在治疗完成后长达24周进行随访。使用客观和主观等级，黄褐斑面积和严重程度指数（MASI），黑色素指数追踪和皮肤弹性测量来评估疗效。结果：研究人员观察到，在治疗后4周，有60％的患者出现临床改善，在患者中有44％，但在治疗后24周，分别下降到52％和35％。平均MASI分数从7.6显着降低到6.2。前两个疗程后，平均黑色素指数显着下降，但在随后的随访中略有复发。治疗没有改变皮肤弹性。在23名受试者中有3名（13％）观察到色素沉着过度。结论：FP治疗黄褐斑导致一些临床改善，但效果不如先前在6个月的随访中报道的有效。我们建议明智地使用FP来治疗亚洲皮肤的黄褐斑，因为它的功效有限。

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