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首页> 外文期刊>Dermatologic surgery >In-transit Merkel cell carcinoma treated with isolated limb perfusion or isolated limb infusion: a case series of 12 patients.
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In-transit Merkel cell carcinoma treated with isolated limb perfusion or isolated limb infusion: a case series of 12 patients.

机译：孤立性肢体灌注或孤立性肢体灌注治疗的转运默克尔细胞癌：12例病例。

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摘要

BACKGROUND: In-transit metastases of Merkel cell carcinoma (MCC) are an unusual and therapeutically challenging manifestation of the disease. Given the similarity to melanoma, in-transit MCC may be amenable to isolated regional therapy. OBJECTIVE: To present a case series of 12 patients who underwent isolated limb perfusion (ILP) or isolated limb infusion (ILI) for in-transit MCC. METHODS: A literature search was conducted using Medline and Pubmed databases for MCC, ILP, and ILI as key words. Ten cases were identified and reviewed; two cases from our hospital were also included in the series. RESULTS: Nine patients underwent ILP, and three were treated with ILI. Eleven patients had a complete clinical response, and one had a partial response. All patients avoided limb amputation. Mean follow-up was 25.3 months. Mean duration of response was 21.8 months. Four patients relapsed regionally. Two patients developed distant metastases and died of their disease. CONCLUSION: This is the largest case series of in-transit MCC treated with ILP or ILI. Both techniques appear to be a low-morbidity alternative to amputation for the treatment of isolated extremity in-transit MCC. ILI is less invasive than ILP and may be a more practical first-line treatment option. The authors have indicated no significant interest with commercial supporters.
机译：背景：默克尔细胞癌（MCC）的转移途中转移是该疾病的异常和治疗挑战性表现。鉴于与黑色素瘤的相似性，转运中的MCC可能适合单独的区域治疗。目的：介绍12例因过境MCC接受独立肢体灌注（ILP）或独立肢体灌注（ILI）的患者。方法：使用Medline和Pubmed数据库以MCC，ILP和ILI作为关键词进行文献检索。确定并审查了十起案件;该系列还包括了我院的两个病例。结果：9例患者接受了ILP，其中3例接受了ILI治疗。 11名患者有完整的临床反应，其中1人有部分反应。所有患者均避免肢体截肢。平均随访25.3个月。平均反应持续时间为21.8个月。四名患者局部复发。两名患者发生远处转移并死于疾病。结论：这是经ILP或ILI治疗的最大的在途MCC病例系列。两种技术似乎都是截肢的一种低发病率替代品，用于治疗孤立的肢体运输中MCC。与ILP相比，ILI的侵入性较小，可能是更实用的一线治疗选择。作者表示对商业支持者没有太大兴趣。

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