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首页> 外文期刊>Dermatologic surgery >Greater collagen deposition with the microneedle therapy system than with intense pulsed light.
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Greater collagen deposition with the microneedle therapy system than with intense pulsed light.

机译：与强脉冲光相比，微针治疗系统的胶原蛋白沉积更大。

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BACKGROUND: Intense pulsed light (IPL) and the microneedle therapy system (MTS) are currently available for the treatment of scars. Greater collagen deposition has been proposed as a mechanism for the treatment of scars. OBJECTIVE: To compare the effects of IPL and MTS on collagen deposition. MATERIALS AND METHODS: Fifty-four imprinting control region mice were divided into three groups: untreated controls, treatment with IPL, and treatment with MTS. A single pass of IPL 10.5 J/cm(2) and five passes (total 15 strokes) of MTS were performed three times every 2 weeks. Four weeks after the last treatment, skin thickness measurements using a caliper, microscopic examination, Western blot analysis for type I collagen, and enzyme-linked immunosorbent assay for total collagen content were performed. RESULTS: Measured using calipers, MTS, resulted in greater skin thickness than IPL that paralleled the dermal thickness of the biopsied specimens. MTS also increased expression levels of type I collagen and total collagen content more than IPL. IPL effects were superior to control. CONCLUSION: MTS increased collagen deposition more than IPL, and MTS might be more effective than IPL for scar treatment. The authors have indicated no significant interest with commercial supporters.
机译：背景：强脉冲光（IPL）和微针治疗系统（MTS）当前可用于治疗疤痕。已经提出更大的胶原蛋白沉积作为治疗疤痕的机制。目的：比较IPL和MTS对胶原沉积的影响。材料与方法：54只印迹控制区小鼠分为三组：未处理的对照组，IPL处理和MTS处理。每两周进行一次IPL 10.5 J / cm（2）的单次通过和MTS的五次通过（总共15次冲程）。最后一次治疗后四周，使用卡尺测量皮肤厚度，显微镜检查，I型胶原蛋白的Western印迹分析以及总胶原蛋白含量的酶联免疫吸附法。结果：使用卡尺MTS进行测量，其皮肤厚度大于IPL，后者与活检标本的真皮厚度平行。与IPL相比，MTS还增加了I型胶原蛋白的表达水平和总胶原蛋白含量。 IPL效果优于对照。结论：MTS比IPL增加了更多的胶原蛋白沉积，MTS可能比IPL更有效地治疗疤痕。作者表示对商业支持者没有太大兴趣。

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