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首页> 外文期刊>Dermatologic surgery >Direct Quantitative Comparison of Molecular Responses in Photodamaged Human Skin to Fractionated and Fully Ablative Carbon Dioxide Laser Resurfacing
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Direct Quantitative Comparison of Molecular Responses in Photodamaged Human Skin to Fractionated and Fully Ablative Carbon Dioxide Laser Resurfacing

机译：在光损伤的人类皮肤中对部分和完全烧蚀性二氧化碳激光换肤的分子反应的直接定量比较

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摘要

BACKGROUND Fractionated ablative laser resurfacing has become a widely used treatment modality. Its clinical results are often found to approach those of traditional fully ablative laser resurfacing. OBJECTIVE To directly compare the molecular changes that result from fractionated and fully ablative carbon dioxide (CO_2) laser resurfacing in photodamaged human skin. METHODS AND MATERIALS Photodamaged skin of 34 adult volunteers was focally treated at distinct sites with a fully ablative CO_2 laser and a fractionated CO_2 laser. Serial skin samples were obtained at baseline and several time points after treatment. Real-time reverse transcriptase polymerase chain reaction technology and immunohistochemistry were used to quantify molecular responses to each type of laser treatment. RESULTS Fully ablative and fractionated CO_2 laser resurfacing induced significant dermal remodeling and collagen induction. After a single treatment, fractionated ablative laser resurfacing resulted in collagen induction that was approximately 40% to 50% as pronounced as that induced by fully ablative laser resurfacing. CONCLUSIONS The fundamental cutaneous responses that result from fully ablative and fractionated carbon dioxide laser resurfacing are similar but differ in magnitude and duration, with the fully ablative procedure inducing relatively greater changes including more pronounced collagen induction. However, the molecular data reported here provide substantial support for fractionated ablative resurfacing as an effective treatment modality for improving skin texture.
机译：背景技术分级烧蚀激光换肤已经成为一种广泛使用的治疗方式。经常发现它的临床结果接近传统的完全烧蚀性激光重铺表面的方法。目的直接比较由光致损伤的人类皮肤中经分馏和完全烧蚀的二氧化碳（CO_2）激光重铺表面产生的分子变化。方法和材料用完全烧蚀的CO_2激光和分次的CO_2激光在不同部位聚焦治疗了34名成年志愿者的光损伤皮肤。在治疗后的基线和几个时间点获得系列皮肤样品。实时逆转录酶聚合酶链反应技术和免疫组织化学被用来量化对每种类型激光治疗的分子反应。结果完全消融和分次的CO_2激光表面重铺可引起明显的皮肤重塑和胶原蛋白诱导。在单次治疗后，分级烧蚀激光换肤导致的胶原蛋白诱导率大约为完全烧蚀激光换肤诱导的40％至50％。结论完全消融和分次二氧化碳激光表面重铺产生的基本皮肤反应相似，但幅度和持续时间不同，完全消融手术可引起相对较大的变化，包括更明显的胶原诱导。但是，这里报道的分子数据为分馏消融表面重塑作为改善皮肤质地的有效治疗方法提供了实质性支持。

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