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首页> 外文期刊>Dermatologic surgery >Review of the hair follicle origin hypothesis for basal cell carcinoma.
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Review of the hair follicle origin hypothesis for basal cell carcinoma.

机译：基底细胞癌的毛囊起源假说的综述。

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BACKGROUND: Basal cell carcinoma (BCC) is the most common type of skin cancer treated by the dermatologic surgeon. The discovery that patients with the nevoid BCC syndrome had mutations in the human homologue of the Drosophila patched gene led to a rapid increase in our understanding of the pathogenesis of BCC. It is theorized that altered regulation at multiple steps in the patched signal transduction pathway may contribute to the development of BCC. This pathway also plays an essential role in embryonic hair follicle development and during the hair cycle. Taken together, a considerable body of evidence suggests that at least some BCC may be derived from deregulated patched signaling in hair follicle stem cells. OBJECTIVE: To review evidence of a follicular derivation of BCC and to highlight emerging therapeutic strategies to block deregulated patched signaling in BCC. CONCLUSION: Deregulation of the patched signal transduction pathway is present in the vast majority of human BCCs. Pharmacologic inhibitors of this pathway may offer a therapeutic strategy to block tumor growth. The author has indicated no significant interest with commercial supporters.
机译：背景：基底细胞癌（BCC）是由皮肤科外科医生治疗的最常见类型的皮肤癌。患有避免性BCC综合征的患者在果蝇修补基因的人类同源物中发生突变的发现导致我们对BCC发病机理的了解迅速增加。从理论上讲，修补信号转导途径中多个步骤的调控改变可能有助于BCC的发展。该途径在胚胎毛囊发育和头发周期中也起着重要作用。综上所述，大量证据表明至少有一些BCC可能来自毛囊干细胞中信号传导失调。目的：回顾BCC滤泡来源的证据，并强调新兴的治疗策略，以阻止BCC中信号传导失调。结论：绝大多数人类BCC中都存在对信号转导通路的调节失调的情况。该途径的药物抑制剂可提供治疗肿瘤的方法。作者表示对商业支持者没有太大兴趣。

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