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Formation of fibrosis after nonablative and ablative fractional laser therapy

机译：非烧蚀性和烧蚀性部分激光治疗后纤维化的形成

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Background Fractional laser therapy (FLT) has become a widely accepted modality for skin rejuvenation and has also been used in various other skin diseases. Objective To observe long-term histologic effects of nonablative and ablative FLT in the treatment of pigment disorders. Methods A randomized controlled observer-blinded study was performed in 18 patients with pigment disorders. Two similar test regions were randomized to receive FLT with intermittent topical bleaching or topical bleaching alone. Patients with ashy dermatosis (AD) and postinflammatory hyperpigmentation (PIH) were treated using nonablative 1,550-nm FLT (15 mJ/microbeam, 14-20% coverage), whereas patients with Becker's nevus (BN) were treated with ablative 10,600-nm FLT (10 mJ/microbeam, 35-45% coverage) for three to five sessions. Biopsies were obtained 3 months after the last treatment. Results At follow-up, dermal fibrosis was observed in four of eight patients treated using ablative FLT and no patients treated using nonablative FLT (p <.05). Conclusions Assuming that the dermal response is comparable in AD, PIH, and BN, at the given settings, ablative FLT may induce fibrosis, whereas treatment with nonablative FLT does not. Whether formation of fibrosis has to be regarded as dermal remodeling or a subtle subclinical form of scarring should be investigated in future research.
机译：背景技术分数激光疗法（FLT）已成为皮肤复兴的一种广泛接受的方式，也已用于多种其他皮肤疾病。目的观察非消融性和消融性FLT治疗色素紊乱的长期组织学效果。方法对18例色素异常患者进行了一项随机对照的观察者盲研究。将两个相似的测试区域随机分配接受间歇性局部漂白或单独局部漂白的FLT。使用非烧蚀性1,550 nm的FLT（15 mJ / microbeam，覆盖率14-20％）治疗患有无菌性皮肤病（AD）和发炎后色素沉着（PIH）的患者，而使用消融性10,600 nm FLT来治疗患有贝克尔痣（BN）的患者。 （10 mJ /微束，覆盖率35-45％）进行三到五个疗程。最后一次治疗后3个月获得活检。结果随访时，在使用消融性FLT治疗的8例患者中有4例观察到了皮肤纤维化，而使用非消融性FLT治疗的患者中没有观察到皮肤纤维化（p <.05）。结论假设在给定的情况下，AD，PIH和BN的皮肤反应相当，消融性FLT可能会诱发纤维化，而非消融性FLT则不能。是否应该将纤维化的形成视为真皮重塑或疤痕形成的微妙的亚临床形式应在未来研究中进行研究。

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