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An investigation of coagulation cascade activation and induction of fibrinolysis using foam sclerotherapy of reticular veins

机译：网状静脉泡沫硬化治疗凝血级联反应和纤溶诱导的研究

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Background Coagulation parameters have not been investigated when foam sclerotherapy is used to treat reticular leg veins. Objective To evaluate the effect of foam bubbles on coagulation and fibrinolysis by measuring platelet count and concentrations of clotting factors and fibrinogen after foam sclerotherapy with sodium tetradecyl sulfate (STS) mixed with room air. Materials and Methods Patients with reticular veins received treatment with up to 30 mL of foam sclerotherapy prepared with STS and room air in a 1:4 ratio (1 mL STS, 4 mL room air) using the double-syringe technique. Venous blood was drawn immediately beforesclerotherapy and 15 minutes after the procedure. Pre- and post-treatment laboratory values were compared. Results Subjects treated with up to 30 mL of foam (30 mL foam = 6 mL sclerosing solution and 24 mL air) showed no statistically significant difference in coagulation or fibrinolysis, as measured according to platelet count and concentrations of clotting factors and fibrinogen, after foam sclerotherapy with STS mixed with room air. Conclusion STS foam made with room air, up to 30 mL, when injected into reticular veins does not affect coagulation parameters.
机译：背景技术当使用泡沫硬化疗法治疗网状腿静脉时，尚未研究凝血参数。目的通过测量十四烷基硫酸钠（STS）与室内空气混合后进行泡沫硬化治疗后的血小板计数，凝血因子和纤维蛋白原浓度，评估泡沫气泡对凝血和纤维蛋白溶解的影响。材料和方法网状静脉患者接受双针技术，以30：1的STS和室内空气以1：4的比例（1 mL STS，4 mL室内空气）配制的泡沫硬化疗法进行治疗。立即在硬化治疗前和手术后15分钟抽取静脉血。比较治疗前后的实验室值。结果根据泡沫后的血小板计数以及凝血因子和纤维蛋白原的浓度进行测量，使用最多30 mL泡沫（30 mL泡沫= 6 mL硬化溶液和24 mL空气）治疗的受试者在凝结或纤维蛋白溶解方面无统计学显着差异。 STS硬化疗法与室内空气混合。结论当注射至网状静脉时，用30毫升的室内空气制成的STS泡沫不会影响凝血参数。

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