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首页> 外文期刊>Dermatologic surgery >An exploratory study to determine the association between assessed facial skin aging and plasma isoprostane levels in middle-aged Japanese women
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An exploratory study to determine the association between assessed facial skin aging and plasma isoprostane levels in middle-aged Japanese women

机译：一项探索性研究，旨在确定评估的中年日本女性面部皮肤老化与血浆异前列腺素水平之间的关联

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摘要

Background One of the central mechanisms of aging is hypothesized to be oxidative stress. Quantification of oxidative stress in human organ systems has been difficult. One of the best methods is using plasma isoprostane levels, which have been shown to reflect oxidative stress in multiple nondermatologic organ systems. Objective To determine whether severity of aging of human skin is associated with plasma isoprostane levels, specifically prostaglandin F2a (PGF2a) and 8-iso-PGF2a while controlling for covariates such as body mass index, ultraviolet light exposure, diet, medication, supplement use, and stress levels. Methods and Materials Facial skin aging assessments performed by four blinded dermatologists were correlated with plasma isoprostane levels in 46 healthy, nonsmoking Japanese women aged 45 to 60. Results Individuals whose assessed skin age exceeded chronological age had mean plasma isoprostane levels of PGF2a and 8-iso-PGF2a that were higher than those whose skin age was assessed to be less than chronological age (p =.001 and.001, respectively). These results remained statistically significant when adjusted for confounding variables (8-iso-PGF2a, p =.02; PGF2a, p =.03). Conclusions Plasma isoprostanes as markers of accelerated aging of the skin merit further study.
机译：背景技术假定衰老的主要机制之一是氧化应激。量化人体器官系统中的氧化应激非常困难。最好的方法之一是使用血浆异前列腺素水平，该水平已显示出可在多种非皮肤科器官系统中反映出氧化应激。目的确定人皮肤老化的严重程度是否与血浆异前列腺素水平（特别是前列腺素F2a（PGF2a）和8-iso-PGF2a）相关，同时控制诸如体重指数，紫外线照射，饮食，药物，补充剂使用等协变量，和压力水平。方法和材料由四位盲人皮肤科医生进行的面部皮肤老化评估与46位年龄在45至60岁的健康，禁烟的日本女性血浆异前列腺素水平相关。 -PGF2a高于那些皮肤年龄被评估为小于年龄的人（分别为p = .001和.001）。调整混杂变量后，这些结果仍具有统计学意义（8-iso-PGF2a，p = .02; PGF2a，p = .03）。结论血浆异前列腺素作为促进皮肤老化的标志物，值得进一步研究。

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