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首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Concomitant Patch Test Reactions to Mercapto Mix and Mercaptobenzothiazole: Retrospective Analysis From the North American Contact Dermatitis Group, 1994-2008
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Concomitant Patch Test Reactions to Mercapto Mix and Mercaptobenzothiazole: Retrospective Analysis From the North American Contact Dermatitis Group, 1994-2008

机译：巯基混合物和巯基苯并噻唑的伴随斑块试验反应：1994-2008年北美接触性皮炎组的回顾性分析

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Background: Mercaptobenzothiazole (MBT) and mercapto compounds are primarily used in rubber products. Objective: This study aimed to examine concomitant-positive rates of MBT (1% pet) and the 4-part mercapto mix (MM) (1% pet). Design: This is a retrospective cross-sectional data from the North American Contact Dermatitis Group. Results: A total of 30,880 patients were patch tested to MM and MBT. There were 333 positive reactions to MM and 427 positive reactions to MBT. Ninety-eight patients were positive to MM alone, 192 to MBT alone, and 235 reacted to both. Forty-five percent (192/427) of MBT reactions would have been missed by only testing to MM, and 29% (98/333) of MM reactions would have been missed by testing to MBT alone. Most of these "missed" reactions, however, were doubtful (+/-) or mild (+) (MBT, 65%; MM, 78%), whereas most reactions in patients who reacted to both were moderate (++) and/or strong (+++) (52.3%). Gloves were the most common source. Conclusions: Mercaptobenzothiazole is the preferential screening allergen for mercapto compounds because of the following: (1) greater proportion of missed reactions with MM; (2) greater proportion of doubtful/mild reactions in the missed group for MM; and (3) in the group positive to both, the low rate (2%) of moderate/strong reactions to MM and doubtful/mild reactions to MBT as compared with the converse (21%). Mercapto mix may be useful in an auxiliary rubber series.
机译：背景：巯基苯并噻唑（MBT）和巯基化合物主要用于橡胶产品。目的：本研究旨在检查MBT（1％宠物）和四部分巯基混合物（MM）（1％宠物）的伴随阳性率。设计：这是来自北美接触性皮炎组织的回顾性横断面数据。结果：共有30,880例患者接受了MM和MBT的斑贴测试。对MM有333个阳性反应，对MBT有427个阳性反应。单独有MM的患者有98例，单独有MBT的患者为192例，两者都有235例反应。仅通过对MM的测试将错过百分之四十五（192/427）的MBT反应，而仅对MBT的测试将错过百分之29（98/333）的MM反应。然而，大多数这些“遗漏”反应是可疑的（+/-）或轻度的（+）（MBT，65％; MM，78％），而对这两种反应均反应的患者大多数反应是中度（++）和轻度（+）。 /或强（+++）（52.3％）。手套是最常见的来源。结论：巯基苯并噻唑是巯基化合物的优先筛选过敏原，原因如下：（1）MM漏诊的比例更高; （2）MM错过组中怀疑/轻度反应的比例更高; （3）对MM的中度/强烈反应和对MBT的可疑/轻度反应的发生率均相对较低（21％），两者均呈阳性。 Mercapto混合物在辅助橡胶系列中可能有用。

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