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首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Assessment of Serum 25-Hydroxyvitamin D Levels in Children with Atopic Dermatitis: Correlation With SCORAD Index
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Assessment of Serum 25-Hydroxyvitamin D Levels in Children with Atopic Dermatitis: Correlation With SCORAD Index

机译：特应性皮炎患儿血清25-羟维生素D水平的评估：与SCORAD指数的相关性

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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an immunologic basis. It may have negative medical and social impacts on a patient and his family. Objectives: To assess serum level of vitamin D among children with AD and determine its association with AD severity using the AD Scoring System Index. Study Design: A case-control study. Patients and Methods: Twenty-nine patients with AD in the age group between 2 and 12 years were enrolled in the study. The severity of the disease was determined by the AD scoring system. Thirty controls were recruited. Serum levels of 25-hydroxyvitamin D3 [25(OH)D3] were tested using commercial automated chemiluminescent microparticle immunoassay. Results: The mean value of vitamin D in children with AD was much lower than normal value, and there was a significant difference in the mean values of vitamin D between children with AD (5.4+-1.9 ng/mL) and the controls (28.9+-2.4 ng/mL). Serum 25(OH)D levels were found to be significantly higher in mild AD (14.6+-3.5 ng/mL) compared with moderate (5.5+3.1 ng/mL) or severe AD (0.3+-0.1 ng/mL); P< 0.001. Conclusion: Patients with AD have lower serum vitamin D levels than normal. Vitamin D deficiency might be related to the severity of AD.
机译：背景：特应性皮炎（AD）是一种具有免疫学基础的慢性炎症性皮肤病。它可能对患者及其家人产生负面的医学和社会影响。目的：评估AD儿童维生素D的血清水平，并使用AD评分系统指数确定其与AD严重程度的关系。研究设计：病例对照研究。患者和方法：纳入2至12岁年龄段的29位AD患者。疾病的严重程度由AD评分系统确定。招募了三十名对照。使用商业化的自动化学发光微粒免疫测定法检测血清25-羟基维生素D3 [25（OH）D3]的水平。结果：AD患儿维生素D的平均值远低于正常值，AD患儿（5.4 + -1.9 ng / mL）与对照组（28.9）之间的维生素D平均值存在显着差异+ -2.4 ng / mL）。与中度（5.5 + 3.1 ng / mL）或重度AD（0.3 + -0.1 ng / mL）相比，轻度AD（14.6 + -3.5 ng / mL）的血清25（OH）D水平明显升高; P ＜0.001。结论：AD患者的血清维生素D水平低于正常水平。维生素D缺乏症可能与AD的严重程度有关。

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